Decontamination Of Aseptic Pharmaceutical Isolators Using Vaporized And Aerosolized Hydrogen Peroxide

By Dr. Kamila Gawel, Dr. Tomasz Regula, Dec Group

Aseptic isolators protect sensitive pharmaceutical products and operators during manufacturing and testing. A direct comparison between traditional vaporized hydrogen peroxide (VHP) and aerosolized hydrogen peroxide (AHP) decontamination demonstrates significant operational gains with aerosolized technology. Delivering a dry fog with droplet sizes between 4 and 8 micrometers, AHP creates a dual-action decontamination mechanism involving both vaporized gas and a thin liquid biocidal film on exposed surfaces. This dual approach completes full decontamination and aeration in just 15 minutes compared to 70 minutes for standard VHP, while consuming significantly less biocide. Additionally, compact AHP generators eliminate the need for liquid heating, lowering energy demands and reducing operating costs. Explore the complete comparative study to evaluate decontamination performance metrics and operational benefits.