Diploid SRM

Diploid SRM

Significantly higher productivity leads to higher virus production

Human cells have been used to manufacture a variety of vaccines such as varicella-zoster, polio, smallpox, hepatitis A, measles, mumps and rubella. Traditionally, the only way to culture these cells has been to utilize classical media with 10% serum, one of the highest-cost components in the vaccine process. Human and recombinant human albumin, which is traditionally used in virus production media, also tends to be expensive.

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Diploid SRM helps with the reduction or elimination of both while maintaining high virus titers for vaccine production (Figure 2).

Figure 1. Chicken Embryo Fibroblast growth with classical medium supplemented with 10% FBS and Diploid Growth SRM without serum supplementation. Cells were seeded from a fresh egg prep at 1.5 x 104 cells

Figure 2. MRC-5 cells were seeded at 1.5 x 104 cells/cm2, incubated for 4 days and trypsinized.