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Diploid SRM

Diploid SRM

Significantly higher productivity leads to higher virus production

Human cells have been used to manufacture a variety of vaccines such as varicella-zoster, polio, smallpox, hepatitis A, measles, mumps and rubella. Traditionally, the only way to culture these cells has been to utilize classical media with 10% serum, one of the highest-cost components in the vaccine process. Human and recombinant human albumin, which is traditionally used in virus production media, also tends to be expensive.

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Diploid SRM helps with the reduction or elimination of both while maintaining high virus titers for vaccine production (Figure 2).

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Figure 1. Chicken Embryo Fibroblast growth with classical medium supplemented with 10% FBS and Diploid Growth SRM without serum supplementation. Cells were seeded from a fresh egg prep at 1.5 x 104 cells

Figure 2. MRC-5 cells were seeded at 1.5 x 104 cells/cm2, incubated for 4 days and trypsinized.

 

Thermo Fisher Scientific