Efficient Operations Of The HyPerforma 5:1 Single-Use Bioreactor At Low Working Volume Application Note

The Single-Use Bioreactor with a 5 to 1 turndown ratio was developed in response to end-user interest in operating Single-Use Bioreacors at lower working volumes in order to realize improved seed-train utilization and better mixing throughout drainage. These design changes are available to customers on new systems or as a retrofit kit for water-jacketed HyPerforma Single-Use Bioreactors. The changes allow customers to operate the bioreactor with as low as 20% working volume in 50 L–500 L vessels. The design improvements include the new cross-flow sparger (CFS), which reduces the buildup of CO2 in the headspace when operating at low working volumes.