Engineering Excellence In Container Closure Integrity Testing

By Oliver Stauffer

Ensuring container closure integrity (CCI) is becoming more complex as sterile drug products diversify and regulatory expectations increase. Choosing the right test method is no longer just an operational decision; it is central to patient safety. Explore the essential elements of a scientifically sound CCI approach, from achieving a strong signal‑to‑noise ratio to limiting system variability and preventing measurement drift. Learn why overly complex methods, heavy sample preparation, and poorly designed compensation factors can undermine reliability, and why non-destructive, deterministic techniques often provide the most robust foundation.

For teams refining CCI strategies or reassessing testing technologies, access the full article to gain practical guidance and a clear vision of what best‑in‑class method development should look like.