Myriad considerations, spanning the full complement of pharmaceutical manufacturing stakeholders, influence the containment solution decision-making process in pharmaceutical manufacturing. Plant managers are tasked with the efficient use of floor space and managing capital and consumable expenses. Process engineers worry about the system’s impact on the integrity of the formulation and cross-contamination mitigation. Project engineers wring their hands over user-friendliness and operational efficiency. Environmental health and safety professionals concern themselves with occupational exposure levels.