Glucagon-Like Peptide-1 (GLP-1) Analogues Applications Notebook

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View this collection of application notes about the chromatographic analysis and purification of Glucagon-Like-Peptide-1 (GLP-1) analogues, including Semaglutide, Tirzepatide, Liraglutide, and Exenatide.

GLP-1 analogues are a vital class of medications used to manage type 2 diabetes and obesity. These drugs, which include Semaglutide, Tirzepatide, Liraglutide, and Exenatide, mimic the natural GLP-1 hormone, stimulating insulin, reducing glucagon, and slowing gastric emptying to improve glycemic control and potentially promote weight loss.

The complex nature of these peptide mixtures, often containing closely related sequences, necessitates high-resolution chromatographic separation for purification. This resource explores various methods and column options for the analysis and purification of GLP-1 analogues. This includes reversed-phase methods for general separation, selecting appropriate columns based on particle size for HPLC/UHPLC instruments, and size exclusion chromatography for detecting high molecular weight aggregates. You can access details on specific applications like determining Semaglutide and Tirzepatide in plasma, purification processes, and aggregate analysis. Explore the full set of application notes for comprehensive chromatographic strategies.