Helium Leak Detection On Glass Cartridge Containers

Ensuring the integrity of glass cartridge containers is critical for maintaining product sterility in pharmaceutical applications. This case study explores the use of helium leak detection to evaluate seal quality at two key interfaces: the crimp/cap and the plunger/stopper. By employing a highly sensitive helium mass spectrometry method, even microscopic leak pathways can be identified, far beyond the capabilities of traditional testing techniques. The process involved preparing filled cartridges, isolating seal areas, and conducting controlled helium flow tests to measure leak rates. This advanced approach provides manufacturers with confidence in packaging integrity and product safety.

Discover how helium leak testing sets a new standard for precision and sterility assurance.