This single-use bioreactor provides state-of-the-art functionality, ease of use, and efficiency. The complete Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) system consists of a bioreactor tank and a bioreactor BioProcess Container (BPC), or bag, which is available in 50, 100, 250, 500, 1,000, and 2,000 L sizes. The redesigned HyPerforma bioreactor maintains traditional stirred-tank bioreactor design principles, including specific height-to-diameter ratios and optimized mixer location that deliver optimum cell viability, performance, and scalability from process development through production.
This data sheet provides information on the HyPerforma 5:1 250 L Single-Use Bioreactor system, which includes the tank and standard Bioreactor single-use bag. The single-use bag utilizes dual-sparger design for cultures at nominal volume and a crossflow sparger strategically positioned just above the 20% liquid volume for seed cultures. Both sparge designs have been rigorously tested to provide high kLa values and optimal CO2 stripping for improved pH control and decreased foaming.