Impact Of The Freeze-Drying Process And Lyoprotectants On Nanoparticle Stability

By Dr. Xiuling Lu Ph.D.

Most nanoparticle formulations are in solution with a heterogeneous size distribution. These nanosuspensions can be unstable and subject to problems, such as sedimentation, agglomeration, crystal growth or chemical reactions. Lyophilization can increase the stability of these particles, which also benefits the stability of the drug products incorporated in them.

Read highlights from a recent webinar describing the challenges of freeze-drying nanoparticles and how a group has designed and evaluated solutions to lyophilizing LNPs.