Application Note

2,000 L HyPerforma Single-Use Bioreactor Evaluation

The stirred-tank reactor is the most commonly utilized reactor type in biotechnology. The Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) is designed as a stirred-tank reactor for animal cell culture and has the unique advantage of utilizing completely single-use product contact surfaces. This design is based on years of traditional successful stirred-tank reactor design and operation. Working volumes of 25 L to 2000 L are now supported using this technology.

During the design of each size of S.U.B., care and consideration were given to produce scalable systems capable of delivering consistent performance through the range of working volumes. Multiple factors are considered in selecting a scale-up technique, but generally include heat and gas transfer as well as mixing capabilities of the hardware systems. Since the S.U.B. is based upon the traditional stirred-tank reactor, many of the classical and well understood scale-up/scale-down strategies can be employed. Critical design parameters such as height-to-diameter ratios, agitation design, and control systems have been preserved, enabling the user to scale easily.

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