Maintain hMSC Multipotency After Large Scale Expansion

By S. Carter, J. Granchelli, and T. Stelzer

Whether the requirements are for clinical or research use, obtaining a substantial number of cells can constitute a bottleneck for the investigator. hMSC are good candidates because they are readily expanded in culture, have immunomodulatory potential and can differentiate into the osteogenic, chondrogenic, and adipogenic lineages.