Mixing Selection Considerations For Pharmaceutical Tablet Coating Operations

By Matt Smith

Pharmaceutical tablet coatings generally consist of a sugar or cellulose based binder, plasticizer, film forming agent and colorant. These ingredients are supplied in granulated or powder form for dispersion in aqueous or organic solvents at concentration varying from 10 - 20% depending on the desired coating properties and formula. In addition to enhancing the appearance and aiding identification of the product, tablet coatings perform a number of functions:

• To protect the tablet from moisture and other adverse conditions.
• To lubricate the tablet to ease swallowing.
• To disguise unpleasant tastes.
• To create a barrier between the active ingredient and the gastrointestinal tract.
• To control the release of drug into the body.

Whilst many proprietary coatings are designed to be easily dispersed, a number of problems are frequently encountered when using conventional mixers and agitators. Read how this high shear mixer can overcome all of these manufacturing difficulties.