Application Note

Mixing And Blending Strategies For Emulsified Vaccines

Source: Silverson Machines, Inc.

By Matt Smith

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Adjuvants are substances which improve the immune response to the antigen used in vaccines. When added to an antigen (virus, bacteria, peptides, etc.), an adjuvant - especially an oily adjuvant - can improve the immune response.

SEPPIC adjuvants from the MONTANIDE™ ISA range are ready-to-use oily products, each being specifically designed to be formulated for one type of emulsion (W/O, O/W, W/O/W). The types of adjuvant and emulsion to use are dependant on the targeted pathology and species.

For pathologies like Foot and Mouth Disease (cattle, swine), Avian Influenza or Newcastle Disease (poultry), Water-In-Oil emulsified vaccines based on MONTANIDE™ ISA adjuvants are capable of improving vaccine efficacy via the induction of a strong and long last immunity.

In the case of cancer treatment by immunotherapy, Water-In-Oil adjuvants have shown to provide an efficacious immune response with a long lasting depot effect.

To produce a stable W/O emulsified vaccine with maintained immunity-inducing properties, the manufacturing process must achieve small emulsion droplets (<1 µm) with a monomodal and narrow particle size distribution. The use of high shear energy provided by a Silverson rotor/stator mixer is required to reach this target.

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