Case Study

Mixing Technology Unrivalled In Dispersion Of Hormonal Active Ingredient


A pharmaceutical manufacturer contacted Silverson as they wanted to develop a production process for an intravenous oncological medicine. The medicine would consist of a low viscosity liquid into which a hormone based active ingredient (AI) needed to be dispersed. The nature of the hormone was the challenge in this application as it had to be dispersed finely enough so that the suspension remained stable and didn’t separate over time, but it could not be over-sheared otherwise the associated medical effects could not be guaranteed, leaving a small margin for mixing and dispersing the AI effectively.

This case study reviews how the company performed laboratory trials using a a laboratory scale In-Line mixer, followed by the purchase of a the Silverson 275UHS In-Line mixer from Silverson’s Ultra Sanitary range of mixers to scale up to production scale. The mixer was able to match the results achieved during the laboratory trial with no problems. An additional 275UHS In-Line mixer was purchased shortly after by the customer to continue expanding their production.


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