Modern Mass Spectrometry With The Triple Quad™ 3500 System

SCIEX 3500 hero

This system offers productivity, reliability, and robustness in a modernized entry-level mass spec for today’s analytical laboratories. The Triple Quad 3500 system offers the speed and precision you want from a modern mass spec system, with the legendary performance and dependability you trust from SCIEX technology.

SCIEX Triple Quad™ 3500 LC-MS/MS System

Welcome to the world of LC-MS/MS

If you’re currently running your assays using GC, GC-MS, or HPLC, a bold new world awaits you. Discover how the power of liquid chromatography (LC) coupled with triple quadrupole tandem mass spectrometry (MS/MS) can simplify and consolidate your current assays, dramatically increase your assay quality, and vastly expand the repertoire of assays you can provide – without breaking your budget. With the SCIEX Triple Quad™ 3500 LC-MS/MS system, modern hardware, powerful software, and robust engineering combine to enable lower levels of detection and quantitation than conventional GC and LC workflows, and across a wider range of analytes. You’ll get expert level performance at an entry level price.

The SCIEX Triple Quad 3500 LC-MS/MS system combines the ease of liquid chromatography with its inherently broad analyte applicability, with the quantitative power of triple quadrupole tandem mass spectrometry (MS/MS).

Key Features

Mass Range: 5-2,000 Da

With the same wide mass range as our top-of-the-line triple quadrupole instruments, even high mass compounds will form multiply-charged ions within the range of the Triple Quad 3500 LC-MS/MS system so you don’t have to worry that you’ll miss anything.

Ionization: Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI) probes included

The TurboIonSpray probe enables electrospray ionization and is mild enough to be used for even labile compounds. For ionization of compounds that do not readily form ions in solution such as non polar compounds, the atmospheric pressure chemical ionization (APCI) probe can be used and may provide better sensitivity.

Polarity Switching: 50 msec in MRM and Scheduled MRM modes

Some analytes preferentially form positively charged ions and some form negatively charged ions. This can present a problem if both types exist within the same sample. With polarity switching, you don’t have to choose the polarity of your assay ahead of time. The Triple Quad 3500 LC-MS/MS system will flip back and forth between charge modes throughout your assay so you get the best sensitivity for every analyte.

Detector Type: AcQuRate Pulse Counting CEM

The AcQuRate™ Pulse Counting Channel Electron Multiplier combines the latest in detector technology with a pulse counting overlap correction algorithm. This means more accurate and precise ion detection over a wide dynamic range while maintaining maximum sensitivity.

Scan Types: Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM

Targeted MRM quantitation is just one of the many scan types this powerful instrument can perform. With the 3500 Triple Quad LC-MS/MS system you can take advantage of one of the many additional scan types such as a Product Ion scan for structural determination of an unknown compound, a Precursor Ion or Neutral Loss scan to detect only compounds within a specific class that share a common structural moiety, or a Q1 or Q3 scan to simply determine the mass of a compound. Alternatively, create an assay that combines multiple different scan types for the ultimate in flexibility.