RHOBUST® Downstream Processing Technology
Rhobust® technology is a downstream processing technology for the manufacturing of recombinant proteins and antibodies.
DSM’s proprietary Rhobust® technology is a Second Generation Expanded Bed Adsorption (EBA) technology that provides an elegant solution for direct product capture in the first downstream process unit operation, by combining clarification and product capture into one single step. Centrifugation, depth-filtration and packed bed chromatography can be replaced by one unit operation, resulting in less preparation and process time, lower cost of goods and reduced investment costs.
The RHOBUST technology offers the option of direct product capture from high titer and high density cell culture processes, microbial or yeast processes, and extracts from different sources e.g. plants. RHOBUST is the next generation Expanded Bed Chromatography (EBA) which combines stable expanded beds with no barriers in the system. Clogging of the system is a thing of the past.
RHOBUST Features
- Adsorbents
- Lab-Scale Columns
- Flex Chromatography System
- Disposable Chromatography
- Feasibility Study