Application Note

Scale-Up Evaluation Of The HyPerforma DynaDrive S.U.B.s Part 1: ExpiCHO-S Cells And CHO-S Cells (cGMP banked)

By Jordan Cobia and Ben Madsen, Thermo Fisher Scientific

Cells iStock-999018482

As a molecule approaches commercial launch and more is known about the potential market demand, companies are often faced with the decision to scale up or scale out their manufacturing processes. Generally, when scale-up production vessels of more than 2,000 L, this decision also involves moving from single-use bioreactors (S.U.B.s) to traditional stainless-steel systems.

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