SCIEX M5 MicroLC System

Microflow LC-MS: moving you closer to developing your next successful drug candidate

The M5 MicroLC system is a feature-rich microflow LC-MS solution meant to simplify small and large molecule quantitation and characterization. Inject less of your precious sample, and take advantage of this extremely sensitive, versatile instrument. The M5 MicroLC system helps you save on costs, is eco-friendly with low solvent consumption and low-waste output, and can be integrated with Analyst and SCIEX OS software.

The M5 MicroLC system is the perfect balance of sensitivity and robustness—more sensitive than traditional analytical flow LC, and more flexible and more robust than nanoflow LC — giving you the potential to optimize your critical workflows, today and into the future.

Key Features

• Accuracy/Sensitivity

  Microfluidic control for accurate flow down to 1 µL/min. Quantify with up to a 10x sensitivity improvement over analytical flow LC

• Flexibility

  Easily customizable and compatible with any micro column, you can switch between assays for an unlimited number of potential drug candidates

• Throughput

  Trap-and-elute option with additional gradient pump for fast sample loading

• Use lower flow rates

  With flow rates as low as to 1 µL/min to boost signal, and with vial bottom-sensing technology, you can now get more from your limited sample

• Software

  Compatible with SCIEX OS and Analyst software

Maximize your results with the M5 MicroLC system

Sensitivity, speed, and more

The M5 MicroLC system is engineered to give you maximum performance, flexibility and robustness for your workflow of choice. See how we can put the M5 MicroLC to work for you.

• Reach your LLOQ

  Reach your required LLOQ by achieving up to 10x more sensitivity.

• Use less sample

  Vial-bottom sensing technology helps you get the most from your limited samples.

• Choose your workflow

  Easily customizable, you can use any column, and any chemistry to switch between assays for an unlimited number of potential drug candidates.

• Cost savings

  Reduce your cost per sample with up to 125x less solvent consumption so you can minimize purchase, storage, and disposal costs.

Advanced technology for greater sensitivity

Intelligent microflow LC technology

Experience greater sensitivity, flexibility, and robustness with the advanced technology in the M5 MicroLC system.

• Increased ionization efficiency

  Compared to analytical flow, the lower flow rate range of the M5 MicroLC system delivers a higher percentage of ions into the mass spectrometer so you get greater sensitivity for your precious samples.

• Dual flow path options

  Get dual flow path capability by adding a second gradient pump – Cutting analysis time by giving you the option of taking the trap offline.

• Click and go fittings

  Know your connections are perfect with finger-tight, no tool fittings. Just listen for the click, and you are good to go.

• Microfluidic Flow

  Patented Microfluidic Flow Control technology allows you to get consistent, accurate results without flow splitting.

Sensitive quantification made simple

Additional features

• Customizable

  Choose the columns you need to accomplish your goals

• Integrated solutions

  Pair with SCIEX mass spectrometers and SCIEX OS or Analyst software

• Maximize Uptime

  Utilize trap-and-elute workflow for increased robustness

• Easily implemented

  Ready to work with your existing Turbo V source or OptiFlow Turbo V source

Your next discovery is within reach

The adoption of LC-MS system is becoming more desirable in today’s laboratories due to its high selectivity, accuracy, and precision for analyzing bioanalysis candidates. The M5 MicroLC system offers a complete solution to optimize your biologic workflows, today and into the future.

• Peptide quant

  Quantify signature peptides or therapeutic peptides in complex matrices, such as serum and plasma.

• Antibody quant

  Targeted antibody quant with outstanding sensitivity and linear dynamic range.

• ADC quant

  Accelerate bioanalytical method development for ADCs with high-sensitivity assays for antibody and/or drug payload.

• Small molecule quant

  Enhance small molecule and metabolite analysis with microflow sensitivity.