Solving The Challenges Of Transdermal Patch Package Integrity

Transdermal patches are increasingly favored for drug delivery due to benefits like controlled release and improved patient compliance. However, the safety and efficacy of these patches hinge on the integrity of their packaging. Compromised seals can lead to contamination, reduced potency, or even accidental exposure to potent drugs such as fentanyl. Traditional methods like bubble emission and vacuum decay often fall short because of the limited headspace in patch packaging. Advanced techniques such as Force Decay and Helium Leak Detection offer deterministic, quantitative solutions for detecting leaks and assessing seal quality. These methods provide high sensitivity and reliability, making them ideal for both production and development phases. As demand for transdermal patches grows, robust package integrity testing becomes essential to ensure product safety and maintain regulatory compliance.

Explore the full application note to learn how these technologies safeguard pharmaceutical packaging.