Tablet Edge Erosion – Solutions For Friability

Tablet edge erosion and friability can affect durability, weight, and appearance, with a maximum allowable friability weight loss of 1% per USP. Increasing binder content and reducing lubricant in formulations can improve tablet strength. Optimal tablet design includes rounded edges, reduced cup depth, and careful land selection to prevent chipping and erosion. Tooling maintenance, like restoring punch land width and managing die taper depth, also plays a significant role.

Effective press setup further reduces friability. Setting punch penetration to match die taper depth, using an appropriate fill cam, and leveling the take-off position can protect tablet edges. Slower press and feeder speeds help eliminate entrained air and prevent particle breakdown, while adjusting pre- and main compression improves bonding. Finally, managing hopper head pressure reduces stratification, helping maintain consistent tablet composition.