Natoli Engineering Company, Inc., is the recognized global leader in tablet press tooling manufacturing. Founded on the uncompromising principle to manufacture and deliver only the highest quality tablet compression tooling, presses and replacement parts at a fair price with exceptional customer service, Natoli has been at the forefront of the tablet compression industry for over 40 years. Our state-of-the-art manufacturing facilities, award-winning engineering team and dedicated production crew enables us to offer clients competitive pricing without compromising our high standards of customer service. Trust in Natoli – our staff has the industry knowledge and expertise to understand and meet your exact requirements and requests.


Basic Powder Flow Characterization [USP <1174>]:

A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

Send a test sample of your powder to Natoli Scientific to get your formula characterized following USP <1062> Guidelines (Tablet Characterization Methods) that we have been practicing for over 25 years.

Natoli Scientific is dedicated to developing high-quality affordable products for your market needs.

We provide a formulation design based on a strong scientific understanding and decoding interplay of materials and process parameters to ensure product integrity. We use traditional as well as principles of ‘Quality by Design (QbD)’ to develop robust lead prototype formulations. The early sound scientific investment in product development saves time and money during scale-up and commercial manufacturing.

Natoli Scientific offers manufacturing services of oral solids at a pilot scale and drug products for clinical trials.

We also offer full-scale commercial manufacturing service till you are ready with your own manufacturing facility to avoid delay in the commercial launch.

Team Natoli understands the complexity of the tablet manufacturing process over more than half a century. We are ready to shoulder every step of the tablet manufacturing chain from blending to granulation, to milling, to compression, to coating. Our manufacturing capabilities are backed up by our expert scientific team, who are ready to offer guidance in product development, technical transfers, and scale-ups.

Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.

Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.

Natoli organization is a reputed leader with more than a half century experience in the tablet manufacturing technology.

We understand tablets better. We are here for serving your needs to overcome challenges associated with commercial manufacturing of solid dosage forms across the globe (North America, Europe, Asia).

Our Natoli scientific team uses holistic approach to understand and solve important tableting problems like capping, lamination, picking, and sticking. We integrate scientific information gathered at material, process, and instrument level to understanding and decode root causes of these common tableting issues.

Natoli’s line of affordable tablet presses is designed, engineered, and manufactured in the U.S.A. and built on our decades of experience in the tableting industry. We know our customers want presses that efficiently meet their R&D and/or production needs.

With Natoli you have a choice in your tablet press: R&D or production, single-station or rotary, fully automated or manual. Whatever your need, Natoli’s best-in-class tablet presses can help you optimize tablet quality while saving time and reducing costs.

Setting a New Benchmark for Ease of Operation

The NCF-45 is built for high reliability, safety, smooth operation, and a focus on reduced product loss. This operator-driven machine is designed specifically for medium-scale production lines. The NCF-45 is capable of producing up to 45,000 capsules per hour at 125 RPM—an average of 12 capsules per second!

The NP-155 pharmaceutical tablet press is equipped with essential features that were designed and engineered to produce quality tablets at an affordable price. With its double-sided design, the NP-155 pharmaceutical tablet press produces two tablets per press turret cycle, allowing you to double your tablet production while running at standard single-sided rotary press speeds. The NP-155 provides significant versatility for delivering exceptional tablet quality, consistency, and production.

AIM™ Pro Plus Control System Makes Tablet Production Easy
The Natoli AIM™ Pro Plus control system is a flexible software and hardware architecture that is standard on Natoli production tablet presses. This industry-leading package can be retrofitted to almost any production tablet press to increase production, improve tablet consistency, and provide an easier-to-manage production environment.

Natoli Engineering’s NP-P20A single-station hydraulic tablet press is a favorite for the production of injectable micropellets and for marginal formulations requiring deep-fill. The NP-P20A meets the FDA’s requirements for batch reporting and secure data management under CFR 21 Part 11 compliance.

Natoli Engineering is quickly becoming the leader in R&D tablet presses with this next-generation rotary tablet press. Designed to help solve formulation and scale-up challenges, the NP-RD30 rotary R&D tablet press replicates the design and functionality of a production press. The turret velocity of the NP-RD30 can reach that of production presses, meaning dwell time can be more accurately established during research and development.

Natoli Quick-Release Tablet Tooling allows researchers to test different dwell times during the tablet R&D process without the expense of buying several different sets of tools or the time needed to change complete sets of tooling or turret speed.

Through our Carlisle Precision Encapsulation Parts subsidiary, Natoli Engineering manufactures premium change and spare parts for most major brands of pharmaceutical encapsulation or capsule filling machines.

Natoli Engineering now offers AIM™ Data Acquisition & Analytical Software for the Natoli NP-RD10A research and development tablet press. The combination of AIM™ Software and this R&D tablet press enables the researcher to evaluate formulation properties and identify potential tableting issues—including capping, lamination, sticking/picking, and tablet robustness—during the tablet development process. Plus, the software can optimize tablet tensile strength and lubrication for successful large-scale manufacturing production.

Each service visit will include the following:

  • Preventative Maintenance
  • Equipment inspection (paddle feeder, tachometer, cams, compression rollers, etc.)
  • Turret inspection
  • Additional Operator and Technician Training

Natoli’s line of efficient tablet presses combine remarkable tablet production, automation and dependability.

Natoli Engineering Company, Inc. provides high quality tablet compression tooling, presses, parts, accessories, and services to the nutritional/vitamin supplement industry. With more than 40 years of industry experience, we are uniquely qualified to meet your tableting needs.

Our NP-400 is a 24/7 workhorse that features built in controls and off-the-shelf electronics. A self-lubricated turret and upper and lower cams reduce maintenance costs and provide longer operation time. The NP-400’s compact design is ideal for tablet manufacturers who need a reliable, efficient press to make up to 3,000 tablets per minute.

This economical tablet press was built to last with direct drive gears to reduce wear and decrease slippage. Designed, engineered and manufactured in the USA, this reliable machine can produce more than 280,000 tablets per hour.

The NP-RD10A fits on benchtop areas and is constructed with an electro-less nickel frame. Using this tablet press in lab research significantly helps to improve tablet uniformity, reduce trial-and-error, decrease formulation waste, and save valuable time and effort.

Natoli Metallurgy, a new division of Natoli Engineering is dedicated to the failure analysis of steels used in the pharmaceutical industry. In addition, Natoli Metallurgy has the capability to assist your business in the selection, and treatment, of steels to improve the longevity of your tooling.

At Natoli Scientific, we utilize a network of university, consultant, and resident resources to investigate problems and offer our customers unique solutions to their product formulation and tooling requirements.

Natoli's new pharmaceutical digital inspection microscope is a powerful, user-friendly inspection tool capable of capturing photos and video, recording measurements, and visually inspecting tablets and tooling.

Tablet manufacturers should not overlook tablet design because it is key to the quality of the end product. Poor quality tablets are often caused by poor tablet design; and poor tablet design is often a result of poor communication.

Natoli Engineering Company offers maintenance kits to assist customers who use punches with rotating heads and/or multi-tip punches.

Natoli Tablet Compression Accessories Catalog is packed with hundreds of quality products, helpful tips, and useful information to help companies get the most from their processing equipment.

Natoli offers a wide range of tablet dedusters to suite a variety of needs.

Natoli offers a unique selection of tablet hardness testers.

Clean punches and dies are essential to maintaining the integrity and efficiency of your tooling investment, as well as the quality of your product. Ultrasonic cleaning has long been considered the most effective, nondestructive way to clean tools – from medical instruments to tablet tooling.

Natoli offers a wide selection of inspection and measurement equipment for tablet compression tooling.

Natoli Engineering's new heavy-duty die segment storage system makes the storage, transportation, and set-up of die segments easier than ever!

Natoli announces availability of three new Technical Posters. These posters are sure to be a valuable addition to your manufacturing, maintenance, and research/design departments.

For over 25 years Natoli Engineering Company, Inc. has been instructing the pharmaceutical and related industries. We continue our tradition by inviting you to attend our technical training courses.

Ever wanted to know how to set-up your tablet press? Natoli offers their customers basic “how-to videos” on their website and YouTube channel as a means to better understand basic process of tablet manufacturing.

Natoli offers tablet press rebuilding services for most makes and models of tablet presses.The engineers at Natoli rebuild a variety of tablet press models including Stokes, Fette, Kilian, Korsch, Cadmach and many others.

B' Inspection Kit from Natoli Engineering Company, Inc.

Turret Inspection Kit by Natoli Engineering Company, Inc.

Tooling storage boxes safely store and protect punches and dies. They are constructed of easy-to-clean, FDA-approved materials. Each box contains an easy lift-out tray and nested lid for stacking.

Natoli offers a selection of dial and digital micrometers.

Natoli offers two complete punch polishing kits, in addition to their wide selection of polishing accessories.

Natoli’s outside dial micrometer with an absolute encoder accurately checks punch-working length.

Natoli provides all the necessary items to properly check punch working length, overall length and cup depth for optimal tablet uniformity.

All Natoli turrets manufactured are designed to improve alignment and increase longevity.

Natoli Dust Cups and Bellows are made with FDA-approved materials, and are selected to meet specific requirements for stability, wear-resistance, cleaning, and flexibility.

Natoli carbide tip punches can maintain tablet quality and increase tool life up to 500% by preventing abrasive material from deteriorating punch tips.

With more than 30 years of experience in manufacturing multiple tip tooling, Natoli Engineering is the expert in tooling configurations.

Natoli’s Tool Management-II (TM-II) Software is the most efficient software available to manage your entire tool database.

Natoli’s outside dial micrometer properly checks punch-working length.

The NP-500 Series is a double-sided, single footprint rotary tablet press ideal for high compression ratio products.

With all the necessary tools, Natoli press set-up toolboxes were designed to help you save time when setting up your tablet press.

The Natoli polishing station includes all the necessary supplies and features to quickly and accurately rework and polish a variety of tooling.

Natoli tabletop ultrasonic units ensure consistent cleaning for compression tooling and parts.

A global leader in manufacturing, Natoli Engineering Company delivers superior tablet compression tooling. Every punch and die is produced from quarantined steel and tested for hardness and exact chemical composition by stringent quality specifications.

Natoli’s laser vision system (LVS) punch inspection device is the most powerful and comprehensive tool control and punch inspection device available.

Natoli Has More Than 250,000 Tablet Press Replacement Parts in stock, ready to ship today. We stock everything from die locks, cam tracks and pressure rollers to turrets, feeder assemblies and more. From general needs to custom requests, Natoli quickly processes orders of all sizes and specifications.

Natoli lubricants are engineered to maximize tool life and minimize maintenance cost by providing superior protection.


Natoli Engineering Company, Inc.

28 Research Park Circle

St. Charles, MO 63304


Phone: 636-926-8900

Fax: 636-926-8910

Contact: Dale Natoli