ABOUT US

Natoli Engineering Company, Inc., is the recognized global leader in tablet press tooling manufacturing. Founded on the uncompromising principle to manufacture and deliver only the highest quality tablet compression tooling, presses and replacement parts at a fair price with exceptional customer service, Natoli has been at the forefront of the tablet compression industry for over 40 years. Our state-of-the-art manufacturing facilities, award-winning engineering team and dedicated production crew enables us to offer clients competitive pricing without compromising our high standards of customer service. Trust in Natoli – our staff has the industry knowledge and expertise to understand and meet your exact requirements and requests.

TABLET PRESS TOOLING MANUFACTURING SOLUTIONS

Single-Station Hydraulic Pharmaceutical Tablet Press: NP-P20A Single-Station Hydraulic Pharmaceutical Tablet Press: NP-P20A

Natoli Engineering’s NP-P20A single-station hydraulic tablet press is a favorite for the production of injectable micropellets and for marginal formulations requiring deep-fill. The NP-P20A meets the FDA’s requirements for batch reporting and secure data management under CFR 21 Part 11 compliance.

Tablet Compression Tooling Tablet Compression Tooling

A global leader in manufacturing, Natoli Engineering Company delivers superior tablet compression tooling. Every punch and die is produced from quarantined steel and tested for hardness and exact chemical composition by stringent quality specifications. 

Pharmaceutical Tablet Press Pharmaceutical Tablet Press

Natoli’s line of efficient tablet presses combine remarkable tablet production, automation and dependability.

Natoli Tablet Press Replacement Parts Natoli Tablet Press Replacement Parts

Natoli Has More Than 250,000 Tablet Press Replacement Parts in stack, ready to ship today. We stock everything from die locks, cam tracks and pressure rollers to turrets, feeder assemblies and more. From general needs to custom requests, Natoli quickly processes orders of all sizes and specifications.

Pharmaceutical Tablet Press Repair and Maintenance Pharmaceutical Tablet Press Repair and Maintenance

Each service visit will include the following:

  • Preventative Maintenance
  • Equipment inspection (paddle feeder, tachometer, cams, compression rollers, etc.)
  • Turret inspection
  • Additional Operator and Technician Training
Technical Training Courses Technical Training Courses

For over 25 years Natoli Engineering Company, Inc. has been instructing the pharmaceutical and related industries. We continue our tradition by inviting you to attend our technical training courses.

Pharmaceutical Formulation Evaluation Services Pharmaceutical Formulation Evaluation Services

At Natoli Scientific, we utilize a network of university, consultant, and resident resources to investigate problems and offer our customers unique solutions to their product formulation and tooling requirements.

R&D Tablet Press R&D Tablet Press

The NP-RD10A fits on benchtop areas and is constructed with an electro-less nickel frame. Using this tablet press in lab research significantly helps to significantly improve tablet uniformity, reduce trial-and-error, decrease formulation waste, and save valuable time and effort.

Pharmaceutical Tablet Press Pharmaceutical Tablet Press

This economical tablet press was built to last with direct drive gears to reduce wear and decrease slippage. Designed, engineered and manufactured in the USA, this reliable machine can produce more than 280,000 tablets per hour.

NP-400 Medium-output Single Footprint Rotary Press NP-400 Medium-output Single Footprint Rotary Press

Our NP-400 is a 24/7 workhorse that features built in controls and off-the-shelf electronics. A self-lubricated turret and upper and lower cams reduce maintenance costs and provide longer operation time. The NP-400’s compact design is ideal for tablet manufacturers who need a reliable, efficient press to make up to 3,000 tablets per minute.

NP-500 Rotary Tablet Press NP-500 Rotary Tablet Press

The NP-500 Series is a double-sided, single footprint rotary tablet press ideal for high compression ratio products.

R&D Pharmaceutical Tablet Press: NP-RD30 R&D Pharmaceutical Tablet Press: NP-RD30

Natoli Engineering is quickly becoming the leader in R&D tablet presses with this next-generation rotary tablet press. Designed to help solve formulation and scale-up challenges, the NP-RD30 rotary R&D tablet press replicates the design and functionality of a production press. The turret velocity of the NP-RD30 can reach that of production presses, meaning dwell time can be more accurately established during research and development.

Quick-Release Pharmaceutical Tablet Tooling Quick-Release Pharmaceutical Tablet Tooling

Natoli Quick-Release Tablet Tooling allows researchers to test different dwell times during the tablet R&D process without the expense of buying several different sets of tools or the time needed to change complete sets of tooling or turret speed.

Pharmaceutical Capsule Filling MRO Parts Accessories Pharmaceutical Capsule Filling MRO Parts Accessories

Through our Carlisle Precision Encapsulation Parts subsidiary, Natoli Engineering manufactures premium change and spare parts for most major brands of pharmaceutical encapsulation or capsule filling machines.

Natoli AIM™ Data Acquisition & Analytical Software for the NP-RD10A Tablet Press Natoli AIM™ Data Acquisition & Analytical Software for the NP-RD10A Tablet Press

Natoli Engineering now offers AIM™ Data Acquisition & Analytical Software for the Natoli NP-RD10A research and development tablet press. The combination of AIM™ Software and this R&D tablet press enables the researcher to evaluate formulation properties and identify potential tableting issues—including capping, lamination, sticking/picking, and tablet robustness—during the tablet development process. Plus, the software can optimize tablet tensile strength and lubrication for successful large-scale manufacturing production.

Nutritional Tablet Manufacturing Equipment Nutritional Tablet Manufacturing Equipment

Natoli Engineering Company, Inc. provides high quality tablet compression tooling, presses, parts, accessories, and services to the nutritional/vitamin supplement industry. With more than 40 years of industry experience, we are uniquely qualified to meet your tableting needs.

Pharmaceutical Metallurgical Services Pharmaceutical Metallurgical Services

Natoli Metallurgy, a new division of Natoli Engineering is dedicated to the failure analysis of steels used in the pharmaceutical industry. In addition, Natoli Metallurgy has the capability to assist your business in the selection, and treatment, of steels to improve the longevity of your tooling.

Pharmaceutical Tablet And Tooling Microscope Inspection Pharmaceutical Tablet And Tooling Microscope Inspection

Natoli's new pharmaceutical digital inspection microscope is a powerful, user-friendly inspection tool capable of capturing photos and video, recording measurements, and visually inspecting tablets and tooling.

Tablet Compression Technical Posters Tablet Compression Technical Posters

Natoli announces availability of three new Technical Posters. These posters are sure to be a valuable addition to your manufacturing, maintenance, and research/design departments.

Tablet Press How-To Video Series Tablet Press How-To Video Series

Ever wanted to know how to set-up your tablet press? Natoli offers their customers basic “how-to videos” on their website and YouTube channel as a means to better understand basic process of tablet manufacturing.

Tablet Press Turrets Tablet Press Turrets

All Natoli turrets manufactured are designed to improve alignment and increase longevity.

Press Set-Up Toolboxes Press Set-Up Toolboxes

With all the necessary tools, Natoli press set-up toolboxes were designed to help you save time when setting up your tablet press.

Rotating Head Maintenance Kit Rotating Head Maintenance Kit

Natoli Engineering Company offers maintenance kits to assist customers who use punches with rotating heads and/or multi-tip punches.

Dust Cups Dust Cups

Natoli Dust Cups and Bellows are made with FDA-approved materials, and are selected to meet specific requirements for stability, wear-resistance, cleaning, and flexibility.

Metal Contamination Detection Equipment Metal Contamination Detection Equipment

Natoli Tablet Compression Accessories Catalog is packed with hundreds of quality products, helpful tips, and useful information to help companies get the most from their processing equipment.

Tablet Dedusters Tablet Dedusters

Natoli offers a wide range of tablet dedusters to suite a variety of needs.

Tablet Hardness Testers Tablet Hardness Testers

Natoli offers a unique selection of tablet hardness testers.

Ultrasonic Cleaning For Tablet Tooling Ultrasonic Cleaning For Tablet Tooling

Clean punches and dies are essential to maintaining the integrity and efficiency of your tooling investment, as well as the quality of your product. Ultrasonic cleaning has long been considered the most effective, nondestructive way to clean tools – from medical instruments to tablet tooling.

TM-II LVS Punch Inspection Device TM-II LVS Punch Inspection Device

Natoli’s laser vision system (LVS) punch inspection device is the most powerful and comprehensive tool control and punch inspection device available.

Punch Measurement & Inspection Punch Measurement & Inspection

Natoli offers a wide selection of inspection and measurement equipment for tablet compression tooling.

Polishing Station Polishing Station

The Natoli polishing station includes all the necessary supplies and features to quickly and accurately rework and polish a variety of tooling.

Punch Polishing Kits Punch Polishing Kits

Natoli offers two complete punch polishing kits, in addition to their wide selection of polishing accessories.

Lubricants Lubricants

Natoli lubricants are engineered to maximize tool life and minimize maintenance cost by providing superior protection.

Die Segment Storage Die Segment Storage

Natoli Engineering's new heavy-duty die segment storage system makes the storage, transportation, and set-up of die segments easier than ever!

Pharmaceutical Tablet Designs Pharmaceutical Tablet Designs

Tablet manufacturers should not overlook tablet design because it is key to the quality of the end product. Poor quality tablets are often caused by poor tablet design; and poor tablet design is often a result of poor communication.

CONTACT INFORMATION

Natoli Engineering Company, Inc.

28 Research Park Circle

St. Charles, MO 63304

UNITED STATES

Phone: 636-926-8900

Fax: 636-926-8910

Contact: Dale Natoli

WHITE PAPERS

  • Preventing Sticking And Picking Through Tablet Design
    Preventing Sticking And Picking Through Tablet Design

    Sticking or picking issues are often not detected until transferring the product from research and development to production. Prevent unanticipated problems during scale up and full-scale production by considering tablet compression issues before tablet designs are finalized.

  • Under Pressure: Breaking The Misconceptions Of Maximum Compression Force
    Under Pressure: Breaking The Misconceptions Of Maximum Compression Force

    It is common for tablet manufacturers to exceed the maximum compression force ratings of their tooling to form a quality tablet. However, going beyond the prescribed tooling rating may result in premature tool wear or failure and possible damage to the press. With proper formulation development and tablet design, the tablet press operator should be able to manufacture quality tablets without exceeding the tooling’s maximum compression force rating.

  • Data Gathering And Analysis Necessary In New Tablet Development
    Data Gathering And Analysis Necessary In New Tablet Development

    A significant concern in tablet manufacturing is speed to market. Moving too quickly, however, may cause delayed production, lost product, and missed deadlines. To reduce potential headaches, companies are embracing the principles of Quality by Design (QbD) and utilizing automated data gathering and tablet analysis during research and development. This allows organizations to reduce product development and delivery stress and loss.

  • Understanding The Importance Of Punch Length And Cup Depth
    Understanding The Importance Of Punch Length And Cup Depth

    This paper describes how to understand punch length, how to measure it correctly, and how wear affects length and tablet consistency. It also addresses the importance of specifying cup-depth tolerances.

  • Approaching Tablet Formulation Step-By-Step To Avoid Risks
    Approaching Tablet Formulation Step-By-Step To Avoid Risks

    All formulators need a methodology that gives them reliable and useful information to identify problems before tablet manufacturing begins.

  • Inspecting On The Edge – Understanding Punch Tip Wear
    Inspecting On The Edge – Understanding Punch Tip Wear

    Avoid production quality-related issues by understanding and knowing how to identify the most common causes of punch tip edge wear.

  • Tool Life Expectancy In Pharma Manufacturing
    Tool Life Expectancy In Pharma Manufacturing

    Individual punches and dies may represent a small portion of production costs in relation to the purchase and maintenance of the equipment, such as fluid bed dryers and tablet presses.

  • R&D To Pharmaceutical Product: How To Reduce Costly Scale-Up Problems
    R&D To Pharmaceutical Product: How To Reduce Costly Scale-Up Problems

    When scaling a new drug formulation from the development side of R&D into manufacturing, there is often a reality check with respect to process scale- up and performance of the formulation at production levels. By Chuck Kettler, Director, Natoli Scientific of Natoli Engineering Company, Inc.

  • How To Reduce Costly Scale-Up Problems in Solid Dose Manufacturing
    How To Reduce Costly Scale-Up Problems in Solid Dose Manufacturing

    Problems with capping/lamination and sticking/ picking are often first realized when a formulation is introduced to a level of compression required to supply market demand.

  • Avoid Tablet Production Problems In The Formulation Development Process
    Avoid Tablet Production Problems In The Formulation Development Process

    Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner.

  • The Importance Of Land Width On Pharmaceutical Tablet Design
    The Importance Of Land Width On Pharmaceutical Tablet Design

    Tablet land is beneficial to add strength and durability to the punch tip. But, this hand land may be perceived as making it more difficult to coat the tablet.

  • The Importance Of Steel Quality In Tablet Compression Tooling
    The Importance Of Steel Quality In Tablet Compression Tooling

    In the design and manufacture of tablet compression tooling, nothing is more important than the quality of the materials being used.

  • 8 Ways To Reduce Tablet Manufacturing Costs
    8 Ways To Reduce Tablet Manufacturing Costs

    It's no surprise that in today's struggling economy, companies are facing budget cuts across the board. In an effort to help our customers address these challenges, we put together this list of 8 Ways to Reduce Tablet Manufacturing Costs.

  • Avoiding Capping Or Lamination During Tablet Production
    Avoiding Capping Or Lamination During Tablet Production

    Anyone who has experienced capping or lamination during tablet production knows the frustration that comes from trying to diagnose the issue. This article discusses a possible cause and several solutions.

  • Steps To Increase Tablet Production While Cutting Operating Costs

    Multi-tip tooling is available in two common configurations: assembly (or multi-piece) and solid. When choosing the configuration, consider the tool type, tablet size, and the number of tips per punch. By Dale Natoli, Vice President

  • Keys To Developing Efficient Tablet And Tooling Design

    Tablet compression tooling, commonly referred to as punches and dies, is probably the most misunderstood element of the tablet manufacturing process. Tooling is responsible for the tablet shape and face configurations, and is also an integral factor for an efficient tablet operation. By Dale Natoli, Vice President

  • Time For A World Tablet Tooling Standard

    If your business is in the tablet compression industry, then you are most likely using tablet compression tooling of the standard "B" and or "D" configuration, regardless of the country you are in. Tablet compression tooling is often referred to as tooling, or more commonly, punches and dies. By Dale Natoli

  • Increase Productivity, Decrease Waste: How To Choose The Right Tablet Tooling
    Increase Productivity, Decrease Waste: How To Choose The Right Tablet Tooling

    Choosing the right tooling can increase tablet output, decrease waste and ultimately determine the success of a product launch.

  • Why You Should Be Using Ultrasonic Cleaning
    Why You Should Be Using Ultrasonic Cleaning

    Clean punches and dies are essential to maintaining the integrity and efficiency of your tooling investment, as well as the quality of your product. Ultrasonic cleaning has long been considered the most effective, nondestructive way to clean tools.

  • Increase Tablet Quality By Checking These 7 Inspection Points
    Increase Tablet Quality By Checking These 7 Inspection Points

    Inspecting tooling and press components for wear or defects could be the most important step in improving tablet quality.

  • How Tablet Shape Can Impact Patient Acceptance
    How Tablet Shape Can Impact Patient Acceptance

    First impressions are everything. This is especially true for pharmaceutical, nutritional and confectionery tablets. Discriminating consumers may decide if they will be repeat customers based on a tablet’s appearance and their experience with it. This article discusses the limitations of the flat faced bevel edge and the benefits of a flat faced radius edge tablet design.

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