Newsletter | August 13, 2025

08.13.25 -- The Hidden Failure That Can Ruin Your Batch

Preventing Failures In Synthesis And Chromatography Columns

For oligonucleotide synthesis and chromatography columns, a single failing seal can silently compromise your entire batch, leading to significant product loss and costly downtime. How can you prevent these invisible threats from becoming massive disruptions? Learn how crucial seal maintenance can prevent failures and safeguard your products.

 

The Hidden Threat To Product Purity: Neglected Seals In Synthesis Columns

Seemingly minor components like seals can pose significant risks to product purity. Overlooking them can lead to contamination and costly delays. Explore how to strengthen contamination control by embedding seal oversight into operational workflows.

 

Don't Let Seals Break Your Batch: A Risk-Based Approach To Column Maintenance

Relying on outdated, one-size-fits-all maintenance schedules for seals can lead to expensive batch failures, downtime, and regulatory noncompliance. Instead, a risk-based approach can provide a more intelligent path forward.

 

Seal Replacement As A Cost Avoidance Strategy

Routine seal replacement is often seen as a minor maintenance task. However, this small operational investment is a proactive cost-avoidance strategy that prevents costly contamination events and regulatory non-compliance. Learn how a proactive seal management program can deliver real ROI in regulated manufacturing environments.

 

Equipment And Support For Optimal Scale-Up

Columns play an outsized role in the successful scale-up of oligonucleotide therapeutics, and Static Compression Synthesis columns offer a simple, robust, and flexible option for developers.

 

SOLUTIONS

Dynamic And Ergonomic Oligosynthesis Column

These patented synthesis columns offer oligonucleotide manufacturers a system designed for efficiency and safety. Key benefits include a 9-step guide for seamless column changeover and technical support and services for the THESYS products.

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