Unlocking Robust, Reproducible Separations For Modern Peptide Therapeutics With BioResolve™ Peptide Phenyl Hexyl+ Columns

By Emery Domain, Caitlin Hanna, and Steve Shiner

As GLP-1 receptor agonists and related peptide therapeutics become more chemically and structurally complex, impurity profiling requires chromatography that can deliver both sensitivity and consistency. The Waters BioResolve Peptide Phenyl-Hexyl+ 1.6 µm Column is built for this analytical challenge, supporting high-confidence separation of incretin mimetic drugs and related compounds. Performance data show strong batch-to-batch and column-to-column reproducibility, low injection carryover, and stable chromatography across 500 injections—key factors for laboratories working to characterize impurities with confidence. For teams developing, manufacturing, or testing modern peptide therapeutics, these results highlight a purpose-built approach to achieving reliable peptide analysis.

Access the full application note to see how the column performs under demanding GLP-1 impurity profiling conditions.