The pharmaceutical industry has undergone a sea of change in recent years as manufacturers have adapted to the end of the era of large-volume production of mass-market blockbuster drugs. With firms now focusing in on subpopulations of patients, there is a need for lean, adaptable facilities that can switch quickly between multiple products in multiple formats. Modular facilities can meet this need. While not a panacea, for the right project characteristics, ‘Modularity in Design’ can deliver significant and quantifiable long-term value.
A common problem statement in the pharmaceutical industry is low oral bioavailability of drug candidates with poor aqueous solubility.
With the aim of reducing costs, Normon planned to significantly increase its batch sizes for certain products. The manufacturer needed to pay close attention to the high quality and safety standards and economic aspects, as well as flexible production sizes and times.
The inability to uniformly disperse powders into a liquid batch within a practical amount of time is an all-too-common mixing problem that impacts productivity, labor costs, and power consumption. This white paper explores five tips for dispersing powders into liquid more efficiently.
Medical prescription drug errors by doctors, pharmacists and patients account for 1.5 million incidences of sickness, injuries or deaths in the U.S. each year. By Jay Anbil and Steve Yoder
From a recent survey conducted within the pharmaceutical industry, by Colorcon, it was confirmed that oral solid dosage forms are a preferred choice for formulation of pediatric medicines.
Formulation scientistsmust develop and validat robust systems that address the challenges posed by increasingly complex drug candidates, in ever shortening time frames.
Capsule integrity is a given for established manufacturers with impeccable reputations. Consumers, however, know from experience that not all capsules are made equal. Some can be difficult to extract from the blister pack. Others may have gel caps with cracks or, even worse, ruptures that allow the ingredients to spill out. Is this a manufacturing problem? Or has R&D neglected to implement a fool proof test methodology for evaluating capsule stability? Compression and tension testing offer a technical approach with quantifiable results that can be used to assess capsule performance.
Some active pharmaceutical ingredients are not soluble. In fact, more than 40% of new chemical entities developed in the pharmaceutical industry have little or no solubility in water.
Hard and soft-shell capsules are utilized in large quantities every day in pharmaceutical and nutraceutical plants around the world. By Bob McGregor, General Manager, Brookfield Engineering
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