Product Inspection White Papers & Case Studies
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Absorption Vs. Ultraviolet-Visible Range Spectrophotometry
Spectrophotometry is a technique employed when quantitative measurement and analysis of specific spectra of light is required. From simple quality assurance techniques to advanced chemical analysis, spectrophotometry is a robust and widely used process that spans multiple disciplines and industries. By Randy Klimek
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Advanced Leak Test Methods
A major pharmaceutical company in North America was using the dye ingress testing method, and found it was not only slow and operator dependent (not reliable), causing false accepts.
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Rupture Test: A Quick and Easy Way to Avoid Soft Gel Capsule Failure
When soft gel capsules rupture during production, packaging or subsequent handling, the damage is oftentimes more extensive than just the single capsule that fails. When consumed by patients, if the active ingredients in soft gel capsules fail to escape as designed at the appropriate time (by rupture, dissolution, or melting), then the product is a failure. Both types of problems are due to non-conforming capsule film strength. How can you predict these types of problems before they occur? Performing a simple rupture test is the quickest way to avoid these potential disasters.
By Eric Chiang, Product Manager, Brookfield
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Determination Of Cell Aggregation In Bacteria Cultures With An Automatic And Reliable Method
The percentage of aggregates in bacteria cultures may be determined by employing the Coulter Principle, also known as Electrical Sensing Zone (ESZ) technique. The ISO International Standard 13319 describes this technique.
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Calculate The Size Distribution Of Non-Spherical, Sub-Micron Particles
Nearly all laser-based particle-sizing devices make no allowance for the shape of the materials under test, regardless of the size of the particles. The reason for this lies with the underlying assumptions used for calculating size distributions from the raw data generated during the analysis.
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Can You Syringe A BioScience Material?
Bioscience engineering is producing an array of new materials for use in the human body. Dental adhesives, ophthalmic fluids, bone joint fillers are but a few of the examples. Physical property testing is needed to qualify the performance of these materials, both in terms of how they handle as well as their final application within the body.
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Medicinal Sprays: How Do You Test For “Stickiness?"
By Eric Chiang and By Robert G. McGregor, Brookfield Engineering Laboratories, Inc.
Medicinal and pharmaceutical products that are applied by spraying have gained in popularity because they easily coat the targeted surface without need for further spreading action by the consumer. Oral and nasal sprays may actually work with greater rapidity, migrating quickly to the target area and producing a very desirable benefit for the patient in terms of faster relief. How do manufacturers know whether the spray will actually stick to the targeted surface once it arrives?
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Slope’s Effect On Accurate Weighing
We often have customers call in with concerns that their floor is out of level and what affect that will have on their weight readings. The scale is designed with the assumption that the load will be parallel to the direction of gravity and perpendicular to the weighing platform; meaning, there is only a vertical force.
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Destructive Testing: Does Your Hard Tablet Measure Up?
Vitamins and medicines oftentimes come in the form of hard tablets. Manufacturers need to ensure that they hold together from time of manufacture to moment of consumption by the customer. R&D scientists have come up with a battery of tests that can evaluate the physical properties of tablets related to fracturability and crush worthiness. Instruments of choice called “Texture Analyzers” which have come initially from the food industry are being used to perform these tests.
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High-Speed Pharmaceutical Glass Vial Inspection With In-Sight Vision Systems
Few industrial sectors have such stringent quality requirements as the pharmaceutical industry. To meet these exacting specifications, companies are increasingly utilizing intelligent vision systems.