PTI White Papers

1. Experimental Design And Positive Controls For Package Integrity 4/9/2020

   Given that the experimental design has only two conditions, leaking and non-leaking, this variable is extremely important to understand. Proper use of positive controls and knowledge of how alternative approaches are applied to challenge a test method support the validity and reliability of the method.

2. Container Closure Integrity Testing: Sensitivity, Automation, Efficiency 4/6/2020

   Explore the need for sensitive, reliable, and automated container closure integrity testing technologies, and how existing deterministic solutions can help achieve optimum quality assurance goals.

3. Dye Ingress For CCIT: A Poor Bet In A High Stakes Game 3/23/2020

   The dye ingress test method continues to be a widely used test method for container closure integrity. This paper explains why the dye ingress test method is not a suitable approach.

4. Risk Mitigation Of Parenteral Packaging With Container Closure Integrity 7/17/2019

   Parenteral delivery systems are the highest risk packaging application concerning container closure integrity. Leaks that register in the single micron range can introduce a threat of bacterial ingress.

5. An Introduction To Vacuum Decay Leak Testing 10/9/2018

   Vacuum decay is a test method provides significant savings by not wasting product for a leak test, and generates return on investment in under six months for many products.

6. Viscous Products No Match For New Container Closure Integrity Technology 9/5/2018

   New product types and packaging configurations, such as highly viscous formulations, pose a threat to traditional leak-testing methods, challenging current practices for container closure integrity testing. 

7. Container Closure Integrity Testing Of Intravenous Bags 8/21/2018

   A non-invasive, non-subjective solution that is capable of detecting package leaks and invisible defects using a differential pressure transducer leak test system.

8. Understanding Ultrasound Technology To Inspect Pouch Seals

   Traditional test methods of testing pouch seals are often destructive and can be unreliable. However, ultrasound technology offers a non-destructive means to ensure pouches are airtight.

9. Understanding Pressure Decay Leak Testing For Bottles And Containers

   Leak detection of empty containers — before the filling and sealing process — is an important step to insure container integrity. Applications in the plastic, blow molding, food, beverage and pharmaceutical industries all require some type of online container integrity system. Submitted by PTI - Packaging Technologies & Inspection

10. Deconstructing The Blue Dye Leak Test Method

    Blister package manufacturing for tablets and capsules has process and material parameters that are unique to each product. Barrier properties of blister packaging are primarily designed to eliminate moisture ingress, a result of H2O molecules passing through micro leaks over extended periods of time. By Oliver Stauffer, PTI Packaging and Inspection Systems