In 2014, the contract manufacturing market for solid dosage forms is anticipated to be $19.6B, representing 58% of the total CMO market value of $33.7B. While the market value percentage for solid dose has been drifting downward — likely related to the shift towards biologics, which are more expensive to develop and manufacture — the propensity to outsource oral solid dosage forms continues to grow modestly.
Natoli Engineering Company recently completed a successful Factory Acceptance Test (FAT) with a top-tier cosmetics company.
When scaling a new drug formulation from the development side of R&D into manufacturing, there is often a reality check with respect to process scale- up and performance of the formulation at production levels. By Chuck Kettler, Director, Natoli Scientific of Natoli Engineering Company, Inc.
Almac has developed a flexible paediatric dosage form consisting of minitablets filled into stickpacks using a robust manufacturing and filling process suitable for routine commercial manufacture.
Compression tooling and tablet press manufacturers are faced with ongoing challenges in the tablet manufacturing environments. Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner. These services should include: press operator training, maintenance/calibration services, quick delivery of replacement parts, tooling, tablet design and powder formulation support.
Clinical studies on solid dose products may require a placebo. The placebo, in the case of a tablet, should possess the same shape and color compared to the active product.
In this case study, API (X) is a highly insoluble compound with a particle size of approximately 14 microns and targeted as a powder for oral suspension dosage form.
Pentapack advanced unit dose pharmaceutical blister packaging systems offer the unique capability to package both solid and liquid dose medications with one machine. Medications are clearly identified with bar code labeling software and high resolution label printing.
Ideal for production of middle-sized charges and research applications.
Manual 2-way diverter used for continuous filling of containers with tablets or capsules.
De-agglomeration of powder blocs according to GMP standard.
Compaction and granulation machine for the chemical industry.
The Alexanderwerk PP 150 C is especially designed as a machine which meets the highest requirements and standards of the chemical industry. As the smallest Alexanderwerk model for the chemical sector it provides a roller diameter of 150 mm and a roller width of 75 mm. With a throughput up to 400 kg/h the PP 150 C can be used in a test center, for the research and development as well as for the production.
Using a cyclone on the extraction line facilitates interception of this powder before it ever leaves the process room, enabling high integrity batch reconciliation and minimizing filter replacement.
The 9505 stainless steel pneumatic conveyor is designed for the transfer of empty 00-5 sized capsules. Capsules are emptied into a collection container and dispensed at an adjustable rate into a capsule-filling machine. This unique conveyor uses air power to push the capsules through rigid sanitary piping into a hopper above the capsule-filling machine without damaging the capsules. The Nilfisk product conveying process takes place in perfect hygienic conditions, respecting both the environment and the operators’ health.
