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Enabling High-Performing Perfusion Cell Culture
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By 2025, process intensification, particularly perfusion-based bioprocessing, is projected to account for 35% of biologics manufacturing. This shift towards advanced methods will necessitate enhanced equipment and consumables, creating a significant opportunity to improve scalability, process design, and management. Explore two innovative solutions aimed at boosting process performance.
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Review an example of scaling up a CHO-based bioprocess using the Thermo Scientific™ DynaDrive™ Singe-Use Bioreactor (S.U.B.), highlighting similarities and differences in control parameters and outcomes. The culture carried out in the DynaDrive S.U.B. displayed KPIs that matched or exceeded those of the bench-scale bioreactor, including IgG titer, specific productivity, and cell density.
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This example highlights differences and similarities in control parameters for the process at the 50 L and 500 L scales using both the Thermo Scientific™ 5:1 HyPerforma™ S.U.B. and the DynaDrive S.U.B. product lines. Furthermore, it shows consistent growth profiles and product titers despite differences in gassing and agitation controls.
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The Thermo Scientific™ BioTitan™ Retention Device is an innovative tubing connection solution designed for the concerns caused by traditional cable ties and other retention technologies. We performed a comparative analysis measuring its average pressure tolerances against standard cable ties and two competitor products when used with varied sizes, tubing types, and environmental conditions.
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Fast-Track Your Path To Commercialization
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The Thermo Scientific™ S.U.B. family offers exceptional productivity and automation, with sizes ranging from 50 L to 5,000 L. Together with our single-use harvesting and mixing equipment and knowledgeable application support, easy scale-up can be achieved from process development to production.
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Fluid Management And Nalgene Containment Solutions
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Discover products designed for small to large production volumes that can fulfill your storage, transport, and sampling needs confidently. With a proven track record of high-quality products and the assurance of fast lead times, spend less time searching for a solution and more time creating one.
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• Request Information
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