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Thermo Scientific HyPerforma DynaDrive Single-Use Bioreactors

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A next-level innovation in single-use bioreactors—unmatched design, scalability, and performance

The Thermo Scientific HyPerforma DynaDrive Single-Use Bioreactor (S.U.B.) is our latest innovation in single-use bioreactors, continuing the success of the robust HyPerforma bioreactors first launched in 2006 and updated in 2013. This new design provides improved performance and scalability to larger volumes. This HyPerforma DynaDrive S.U.B. helps ensure optimal cell culture performance across all scales and increased cell densities.

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  • Improved turndown ratio:
    • Uniquely designed to allow mixing at very low volumes
    • 10:1 for the 50 L S.U.B. and 20:1 for the 500 L S.U.B.
    • Seed directly from flasks into S.U.B.
  • Optimized for modern cell culture processes, accommodating high power input per volume (PIV) and volumetric mass transfer performance (measured by kLa)
    • Easily capable of supporting viable cell densities of >100 million cells/mL
    • Scaled PIV and kLa for various terminal volumes
    • Characterized linear kLa performance
  • Considerable savings in CAPEX and OPEX due to reduced seed-train and scale-up processes
    • Reduced steps, labor and documentation required for the seed train processes
    • Minimized contamination risks
    • Improved facility footprint space utilization

Bold hardware design:

  • Ergonomic unit design for easy, consistent, and reliable BPC loading and deployment
  • Cutouts in hardware allow for unique customization and ease of use/access to ports
  • New cubical geometry and design improves mixing by providing baffles in corners and better BPC fit
  • Lower probe cutouts on vessel for accurate sensing of pH, DO, and temperature
  • Bottom-jacketed vessel for better heat transfer and temperature control at lower volumes

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