Cytiva product datasheets, catalogs, app notes

41. Epitope Binning: A Critical Step In Antibody Selection 1/31/2020

    Epitope binning immunoassays using surface plasmon resonance (SPR) can and should be deployed in the development of new potential drug candidates. This article discusses how SPR is used to characterize closely related “bins” of mAbs targeting the same epitope of the target protein and how the selection process is used to develop new vaccines, therapeutic antibodies, and diagnostic tools.

42. Multidimensional Scale-Up Of A mAb Capture Step Contributes To Shortened Time To Market 10/10/2018

    This application note demonstrates a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system.

43. Process-Economy Simulation Of mAb Capture Step With Protein A Chromatography Resin 10/10/2018

    Calculation examples that highlight scenarios where the enhanced capacity and alkaline‑stability of MabSelect PrismA can provide process economic benefits to large‑scale mAb processing.

44. Capacity And Performance Of MabSelect™ PrismA Protein A Chromatography Resin 10/2/2018

    This application note demonstrates the binding capacity of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies.

45. Process Economy Of Using Cytodex Gamma Microcarriers 8/3/2018

    Microcarriers are commonly used in bioreactor cultures to provide a large growth surface for anchorage-dependent cells, and are typically provided either untreated or gamma-irradiated and ready for use.

46. Efficient Purification Of The Pertussis Antigens Toxin, Filamentous Haemagglutinin, And Pertactin In Chromatography Workflows 2/21/2018

    Read how this method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.

47. Automated In-Line Buffer Prep Saves Time And Facility Footprint 2/1/2018

    Buffer preparation is both time- and space-consuming and become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-line conditioning.

48. Continuous Chromatography In Downstream Processing Of A mAb 2/1/2018

    In this study, periodic counter current (PCC) chromatography and straight-through processing (STP) technologies were evaluated in a continuous three-step monoclonal antibody (mAb) purification process.