Formulation Development White Papers & Articles

  1. AI Enabled Pharmaceutical Cocrystal Screening 9/3/2026

    Cocrystal candidate screening is resource-intensive and prone to gaps. This paper examines how AI-based modeling, trained on more than 20,000 data points, can sharpen candidate prioritization without sacrificing scientific rigor.

  2. Looking Beyond Solubility And Process Performance 9/2/2026

    Solvent selection for spray-dried dispersions significantly impacts drug performance, scalability, and supply chains. Early, structured solvent choice is vital for successful manufacturing and commercialization.

  3. How To Achieve Late-Phase Success In Complex OSD Development 8/31/2026

    Late-phase OSD scale-up demands more than technical know-how. This paper examines the frameworks, tools, and partnership models that determine whether promising molecules reach commercial production reliably.

  4. Reducing Uncertainty In Early Oral Drug Development 8/31/2026

    Five recurring decision points in early oral solid dose development carry outsized downstream consequences. AI/ML-driven predictive modeling is reframing how teams manage those decisions under API and timeline constraints.

  5. Lipid Formulation Development: Why Softgels Are The Technology Of Choice 8/31/2026

    Low bioavailability affects roughly 80% of APIs, yet many drug developers default to standard OSD forms. This paper examines why softgels deserve earlier consideration in formulation strategy.

  6. 5 Hidden Risks In Early-Phase OSD Formulation Development 8/31/2026

    Early formulation decisions in OSD development carry risks that may not surface until later stages, when the cost of course correction is significantly higher.

  7. Overview Of Hot Melt Extrusion And Its Pharmaceutical Applications 8/31/2026

    More than 40% of NCEs face aqueous solubility challenges. Here, we examine how hot melt extrusion addresses solubility, modified release, abuse deterrence, and scale-up across pharmaceutical development.

  8. Enabling Flexibility And Scientific Innovation In OSD Development 8/31/2026

    How one clinical-stage CNS biotech navigated early formulation complexity, shifting pipeline priorities, and scalable manufacturing demands through a strategic CDMO partnership.

  9. Robust Database Characterizes And Optimizes Product Development 8/29/2026

    Integrating material characterization data with process parameters accelerates drug development, reduces empirical testing, and strengthens regulatory compliance.

  10. Optimize Process Performance And Maximize HCP Removal 8/27/2026

    Compare filtration strategies and explore how filter selection affects host cell protein removal, processing efficiency, and the balance between impurity clearance and filtration performance.