Material Handling White Papers & Case Studies

  1. In-Situ, Non-Destructive Surface Area Measurement For The Optimal Application Of Lyophilization
    10/2/2019

    A key focus of this paper is the relevant measurement of surface area, with experimental data demonstrating the performance and value of novel instrumentation for in-situ characterization.

  2. Preventing Sticking And Picking Through Tablet Design
    9/6/2019

    Sticking or picking issues are often not detected until transferring the product from research and development to production. Prevent unanticipated problems during scale up and full-scale production by considering tablet compression issues before tablet designs are finalized.

  3. Under Pressure: Breaking The Misconceptions Of Maximum Compression Force
    9/6/2019

    It is common for tablet manufacturers to exceed the maximum compression force ratings of their tooling to form a quality tablet. However, going beyond the prescribed tooling rating may result in premature tool wear or failure and possible damage to the press. With proper formulation development and tablet design, the tablet press operator should be able to manufacture quality tablets without exceeding the tooling’s maximum compression force rating.

  4. Data Gathering And Analysis Necessary In New Tablet Development
    9/6/2019

    A significant concern in tablet manufacturing is speed to market. Moving too quickly, however, may cause delayed production, lost product, and missed deadlines. To reduce potential headaches, companies are embracing the principles of Quality by Design (QbD) and utilizing automated data gathering and tablet analysis during research and development. This allows organizations to reduce product development and delivery stress and loss.

  5. Manufacturer Finds Solution For Transporting HPAPI Product with Containment
    7/10/2019

    A client was in need of a containment enclosure for an analytical weighing and solution-preparation operation involving Highly Potent Active Pharmaceutical Ingredients (HPAPI) in powder form. Their goal was to transfer product from an enclosure to another enclosure. read how Flow Sciences used a recently developed containment device and augmented to fit the specific needs of the client.

  6. Understanding The Importance Of Punch Length And Cup Depth
    4/4/2019

    This paper describes how to understand punch length, how to measure it correctly, and how wear affects length and tablet consistency. It also addresses the importance of specifying cup-depth tolerances.

  7. Venting Fume Hood Base Cabinets — A Better Way
    3/27/2019

    Frequently, companies have used fume hood exhaust to ventilate hood base cabinets. There is both the need for this practice and the designs for them are frequently not well thought-out. 

  8. The Keys To Superior Containment In Compounding Applications
    3/27/2019

    This paper reviews why very bad things happen when either quantity or purity of Highly Potent Active Pharmaceuticals is not properly maintained during the compounding process. Additionally, when highly potent active pharma ingredients are not effectively contained, workers may be adversely affected.

  9. How To Increase The Solubility And Bioavailability With Hot Melt Extrusion?
    3/22/2019

    When executed properly, HME advances poorly soluble compounds in the development pipeline, without adding delays, cost, or significant post-processing activities, and can scale to commercial manufacturing.

  10. Fluid Bed Granulation And Melt Granulation In Pharma Manufacturing
    3/19/2019

    Affording superior reproducibility and control than other granulation techniques, fluid bed granulation and melt granulation can be tightly regulated to produce uniform material with a specified particle size.