Material Handling White Papers & Case Studies

1. Product Development For An Oral Solid Dosage Using Continuous Manufacturing 10/30/2020

   A thorough evaluation using several small-scale studies should be completed to help determine whether continuous or batch manufacturing is the best fit for your product.

2. Pediatric Dosage Form Considerations For Highly Potent Compounds 7/6/2020

   The development of pediatric medicine poses numerous challenges to pharmaceutical formulators, particularly products intended for infants and very young children. This white paper describes special considerations for selecting appropriate pediatric dosage forms and the benefits of choosing mini-tablets (e.g., orodispensible) for pediatric formulation, particularly for highly potent compounds.

3. Extrusion- Spheronization, Engineered For Today’s Controlled Release Forms 6/29/2020

   Synchronizing and controlling API delivery, extrusion-spheronization offers pharmaceutical companies a robust technique to manufacture today’s most complex therapeutics. With the right capabilities, this well-understood process stands ready to help lead the development and manufacturing of both today’s and tomorrow’s complex OSD therapeutics.

4. In-Situ, Non-Destructive Surface Area Measurement For The Optimal Application Of Lyophilization 10/2/2019

   A key focus of this paper is the relevant measurement of surface area, with experimental data demonstrating the performance and value of novel instrumentation for in-situ characterization.

5. Manufacturer Finds Solution For Transporting HPAPI Product with Containment 7/10/2019

   A client was in need of a containment enclosure for an analytical weighing and solution-preparation operation involving Highly Potent Active Pharmaceutical Ingredients (HPAPI) in powder form. Their goal was to transfer product from an enclosure to another enclosure. read how Flow Sciences used a recently developed containment device and augmented to fit the specific needs of the client.

6. Venting Fume Hood Base Cabinets — A Better Way 3/27/2019

   Frequently, companies have used fume hood exhaust to ventilate hood base cabinets. There is both the need for this practice and the designs for them are frequently not well thought-out. 

7. The Keys To Superior Containment In Compounding Applications 3/27/2019

   This paper reviews why very bad things happen when either quantity or purity of Highly Potent Active Pharmaceuticals is not properly maintained during the compounding process. 

8. How To Increase The Solubility And Bioavailability With Hot Melt Extrusion? 3/22/2019

   When executed properly, HME advances poorly soluble compounds in the development pipeline, without adding delays, cost, or significant post-processing activities, and can scale to commercial manufacturing.

9. Fluid Bed Granulation And Melt Granulation In Pharma Manufacturing 3/19/2019

   Affording superior reproducibility and control than other granulation techniques, fluid bed granulation and melt granulation can be tightly regulated to produce uniform material with a specified particle size.

10. Leverage 3D-Printing In Clinical Trials To Accelerate Speed To Market 12/11/2018

    The enhanced precision used in 3D printing can drive efficiencies in early drug development by allowing more flexibility with dosage size and strengths, leading to a more effective use of costly resources.