Material Handling White Papers & Case Studies

  1. Scale-up And Optimization For Tablet Production

    Natoli Engineering Company recently completed a successful Factory Acceptance Test (FAT) with a top-tier cosmetics company.

  2. R&D To Pharmaceutical Product: How To Reduce Costly Scale-Up Problems

    When scaling a new drug formulation from the development side of R&D into manufacturing, there is often a reality check with respect to process scale- up and performance of the formulation at production levels. By Chuck Kettler, Director, Natoli Scientific of Natoli Engineering Company, Inc.

  3. Paediatric Drug Product Development Through To Commercialization

    Almac has developed a flexible paediatric dosage form consisting of minitablets filled into stickpacks using a robust manufacturing and filling process suitable for routine commercial manufacture.

  4. Avoid Tablet Production Problems In The Formulation Development Process

    Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner.

  5. How A Placebo Formulation Is Designed For An Oral Solid Dose Product

    Clinical studies on solid dose products may require a placebo.  The placebo, in the case of a tablet, should possess the same shape and color compared to the active product.

  6. In Vivo Study And The Impact Of The Dissolution Rate On Bioequivalence

    Comparative human in-vivo study of an immediate release tablet over-encapsulated by gelatin and hydroxypropyl methyl cellulose capsules – impact of dissolution rate on bioequivalence.

  7. Case Study: Bag Handling, Check Sieving, Weigh System

    In this installation, materials are received in 50-pound bags and semi-bulk bags and are security screened for foreign objects while being conveyed to a weigh hopper, where they are automatically hatched in predetermined weights and discharged into process drums.

  8. Medication Errors -- A Threat To Patient Safety: Mitigating Errors With Tablet Appearance

    Medical prescription drug errors by doctors, pharmacists and patients account for 1.5 million incidences of sickness, injuries or deaths in the U.S. each year. By Jay Anbil and Steve Yoder 

  9. Film Coating For Pediatric Oral Solid Dosage Forms

    From a recent survey conducted within the pharmaceutical industry, by Colorcon, it was confirmed that oral solid dosage forms are a preferred choice for formulation of pediatric medicines.

  10. Microfeeding Technology Adds New Possibilities For Improved Efficiency And Automation

    Spurred by pharmaceutical industry demand for continuous ultra-low-rate powder feeders where accuracy is measured in milligrams, today’s microfeeding technology adds new possibilities for improved efficiency and automation available to all.