Material Handling White Papers & Case Studies

  1. Precision In Miniature: Optimizing Multiparticulate Formulations For Pediatric Oncology 9/9/2026

    When an oral liquid formulation of crizotinib failed pediatric trials due to intolerable taste and irritation, a multiparticulate approach offered a technically demanding but viable path forward.

  2. Overcoming The Obstacles Of Spray-Dried Dispersion Scale-Up 9/9/2026

    SDD scale-up introduces scale-dependent risks that threaten bioavailability, stability, and manufacturability. This white paper details a model-based framework for managing those risks from early feasibility through commercial production.

  3. Overview Of Hot Melt Extrusion And Its Pharmaceutical Applications 8/31/2026

    More than 40% of NCEs face aqueous solubility challenges. Here, we examine how hot melt extrusion addresses solubility, modified release, abuse deterrence, and scale-up across pharmaceutical development.

  4. Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling 7/15/2026

    Learn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.

  5. Compaction Simulation For Tablet Technology Transfer And Scale-Up 7/15/2026

    Compaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.

  6. Predicting Softgel Stability And Shelf Life Using Accelerated Modeling 7/15/2026

    Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.

  7. Predicting Drug-Loading Limits In Tablet Formulations 7/15/2026

    Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.

  8. Modeling Polymer Interactions To Improve Amorphous Solid Dispersion Stability 7/15/2026

    Molecular dynamics modeling revealed how hydrogen bonding between PVP and Eudragit drives stable amorphous solid dispersion formation, cutting formulation screening time significantly.

  9. Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies 7/15/2026

    In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.

  10. Spray Dry Biologics For Oral Dosage Forms 5/15/2026

    Spray drying enables stable oral delivery of biologics by creating protective dry powders, improving bioavailability, stability, and targeted release compared with traditional formulation methods.