Material Handling White Papers & Case Studies

1. Identifying Abrasive Wear Risks In Tableting Tooling For Nutraceutical Products 2/13/2020

   Tablet presses are used to manufacture a variety of products, such as pharmaceuticals, nutraceuticals, veterinarian products, confectionary, and industrial tablets. Each industry faces unique challenges due to the properties inherent to any particular formulation. A variety of steel types/coatings, tool design modifications/options, and tablet design recommendations can work together to increase tool life and improve tablet quality.

2. Overcoming Encapsulation Issues Caused By Sticky Formulations 2/13/2020

   This guide provides a best-practices approach to troubleshooting capsule-filling problems when handling a sticky product formulation.

3. Considerations When Cleaning Your Tablet Presses & Tablet Tooling 2/13/2020

   Implementing a cleaning procedure is essential to maintaining your tablet tooling and presses. Dirty tools cause tableting and product quality-related problems, such as sticking & picking. Keeping tools clean also decreases premature tool, turret and cam wear, and reduces the risk of product cross-contamination. While most cleaning methods can achieve similar results, utilizing an automated cleaning system, such as an ultrasonic wash with rinse and dryer, can ensure tooling is properly cleaned and dried consistently with limited handling and potential for damage. A warm air-drying process is ideal for preventing moisture and corrosion by pushing warm air through areas, such as key slots, punch cups, and die bores, that may not be dried properly with a traditional towel or cloth.

4. In-Situ, Non-Destructive Surface Area Measurement For The Optimal Application Of Lyophilization 10/2/2019

   A key focus of this paper is the relevant measurement of surface area, with experimental data demonstrating the performance and value of novel instrumentation for in-situ characterization.

5. Preventing Sticking And Picking Through Tablet Design 9/6/2019

   Sticking or picking issues are often not detected. Prevent unanticipated problems during scale-up and full-scale production by considering tablet compression issues before tablet designs are finalized.

6. Breaking The Misconceptions Of Maximum Compression Force 9/6/2019

   With proper formulation development and tablet design the tablet press operator should be able to manufacture quality tablets without exceeding the tooling’s maximum compression force rating.

7. Data Gathering And Analysis Necessary In New Tablet Development 9/6/2019

   A significant concern in tablet manufacturing is speed to market. Moving too quickly, however, may cause delayed production, lost product, and missed deadlines. To reduce potential headaches, companies are embracing the principles of Quality by Design (QbD) and utilizing automated data gathering and tablet analysis during research and development. This allows organizations to reduce product development and delivery stress and loss.

8. Manufacturer Finds Solution For Transporting HPAPI Product with Containment 7/10/2019

   A client was in need of a containment enclosure for an analytical weighing and solution-preparation operation involving Highly Potent Active Pharmaceutical Ingredients (HPAPI) in powder form. Their goal was to transfer product from an enclosure to another enclosure. read how Flow Sciences used a recently developed containment device and augmented to fit the specific needs of the client.

9. Understanding The Importance Of Punch Length And Cup Depth 4/4/2019

   This paper describes how to understand punch length, how to measure it correctly, and how wear affects length and tablet consistency. It also addresses the importance of specifying cup-depth tolerances.

10. Venting Fume Hood Base Cabinets — A Better Way 3/27/2019

    Frequently, companies have used fume hood exhaust to ventilate hood base cabinets. There is both the need for this practice and the designs for them are frequently not well thought-out.