Material Handling White Papers & Case Studies
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Hot Melt Extrusion: Improving Solubility Of Poorly Soluble Compounds
11/30/2021
As you create your hot-melt extrusion (HME) strategy to manufacture amorphous solid dispersions (ASDs), there are several considerations to ensure your plan is flexible, robust, and comprehensive.
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In Vitro Dissolution Methodologies For Amorphous Solid Dispersions
10/25/2021
With the availability of so many types of in vitro dissolution tests, how do you determine which one will be most effective in predicting in vivo performance of your BCS II or IV drug product?
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Product Development For Oral Solid Dose Using Continuous Manufacturing
10/30/2020
A thorough evaluation using several small-scale studies should be completed to help determine whether continuous or batch manufacturing is the best fit for your product.
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Pediatric Dosage Form Considerations For Highly Potent Compounds
7/6/2020
The development of pediatric medicine poses numerous challenges to pharmaceutical formulators, particularly products intended for infants and very young children. This white paper describes special considerations for selecting appropriate pediatric dosage forms and the benefits of choosing mini-tablets (e.g., orodispensible) for pediatric formulation, particularly for highly potent compounds.
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Extrusion- Spheronization, Engineered For Today’s Controlled Release Forms
6/29/2020
Synchronizing and controlling API delivery, extrusion-spheronization offers pharmaceutical companies a robust technique to manufacture today’s most complex therapeutics. With the right capabilities, this well-understood process stands ready to help lead the development and manufacturing of both today’s and tomorrow’s complex OSD therapeutics.
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In-Situ, Non-Destructive Surface Area Measurement For The Optimal Application Of Lyophilization
10/2/2019
A key focus of this paper is the relevant measurement of surface area, with experimental data demonstrating the performance and value of novel instrumentation for in-situ characterization.
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Manufacturer Finds Solution For Transporting HPAPI Product with Containment
7/10/2019
Containment enclosure solution for an analytical weighing and solution-preparation operation involving HPAPI in powder form allows manufacturer to successfully transfer product from an enclosure to another enclosure.
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Venting Fume Hood Base Cabinets — A Better Way
3/27/2019
Frequently, companies have used fume hood exhaust to ventilate hood base cabinets. There is both the need for this practice and the designs for them are frequently not well thought-out.
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The Keys To Superior Containment In Compounding Applications
3/27/2019
This paper reviews why very bad things happen when either quantity or purity of Highly Potent Active Pharmaceuticals is not properly maintained during the compounding process.
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Increase Solubility And Bioavailability With Hot Melt Extrusion
3/22/2019
When executed properly, HME advances poorly soluble compounds in the development pipeline, without adding delays, cost, or significant post-processing activities, and can scale to commercial manufacturing.