MilliporeSigma Articles

  1. Difficult-To-Purify And Difficult-To-Filter Small Molecules 11/3/2026

    Poor filterability and stubborn impurities often trace back to the same molecular features, which changes how development teams approach scale-up for larger, structurally complex small molecules.

  2. Choosing The Right CDMO For Substance Development And Manufacturing 11/3/2026

    Controlled substance programs demand licensing, closed-system custody, and inspection history well beyond GMP. Sponsors weighing partners must test technical depth against compliance infrastructure.

  3. Getting Started On A Successful Path To Microbial QC Automation 10/6/2026

    Moving microbial QC toward automation involves team-building, facility readiness, staff concerns, validation, regulatory alignment, and cost justification that extends well beyond simple labor savings.

  4. A Scalable Analytical Method For Quality-Driven AAV Characterization 7/1/2026

    AEX-HPLC has emerged as a robust, GMP-compatible analytical method for accurately characterizing AAV capsid composition, enabling consistent assessment of empty, partial, and full capsids to support product quality, process development, and regulatory readiness.

  5. A Simple And Powerful Solution For Accelerating Dissolution 5/5/2026

    Many poorly soluble drugs fail not because of low solubility, but because they dissolve too slowly. Learn how focusing on dissolution rate can unlock absorption gains using simple strategies.

  6. Biopharma Supply, Reimagined: Regional, Resilient Manufacturing 4/1/2026

    Persistent disruption is redefining biopharma supply chains. Explore how regional manufacturing, integrated risk management, and closer collaboration help build resilience and improve agility.

  7. How A Specialized CDMO De-Risks Complex API Development 2/24/2026

    Rising API complexity and AI-driven chemistry require specialized CDMOs with technical expertise in hazardous or chiral synthesis to successfully navigate the transition to GMP manufacturing.

  8. A CDMO Is The Nexus Between Green Chemistry And Commercialization 2/24/2026

    Modern R&D transforms sustainability from an optional add-on into a strategic optimization tool, enhancing cost-efficiency, speed to market, and process intensification for drug developers.

  9. Why Reshoring Is An Essential Strategy For ADC Supply Chain Security 2/24/2026

    Biotechs reshoring their supply chains to Western regions to mitigate risk and improve reliability require experienced partners to effectively manage these complex transitions.

  10. Selecting A CDMO For Custom Activated PEGs 1/27/2026

    Custom-activated PEGs require thoughtful planning and precise analytical control. Discover key considerations for selecting a partner capable of supporting scalable, compliant PEGylation.