MilliporeSigma Articles

  1. Studying Analyte Binding To Syringe Filters During Filter Validation 5/2/2022

    Filter validation is a critical part of various pharmaceutical QC tests. Since QC tests require accurate analyte quantitation, analyte binding is an important factor.

  2. Tips To Improve Size-Exclusion Chromatography For mAbs And ADCs 5/2/2022

    In this article, we will explore tips to improve the method of size-exclusion chromatography (SEC), which is often used to measure monomer/aggregate and fragment content of mAbs and ADCs.

  3. Pharma Analysis & Quality Control: Trends From The Rapid Pharma Evolution 4/4/2022

    Discover how the pharma analysis and quality control community envisions future trends and if the challenges faced by your peers are the same as yours.

  4. Robotics & Automation On The Brink Of Transforming Pharma QC 4/1/2022

    In QC, there is still huge potential to accelerate the release of safe products. Here, we review ways to boost the reliability, data integrity, and productivity of microbiological testing.

  5. Alternative Endotoxin, Non-Endotoxin Pyrogen Test Method 2/5/2021

    The ability of the Mono-Mac-6 cell line to detect non-endotoxin pyrogens is sometimes questioned. To demonstrate its performance, tests have been performed using a wide panel of monocytic TLRs ligands.

  6. Bio4C ProcessPad™ 21 CFR Part 11 Compliance 1/12/2021

    Learn how Bio4C ProcessPad™ meets 21 CFR Part 11 requirements including unique usernames and passwords, timestamped audit trails, and secure storage of all records.

  7. Cell Based Potency Assay In Functional Characterization Of mAbs 6/12/2019

    Because characterization and comparison of originator and biosimilar candidate mAbs is challenging due to their complex and variable structures, a range of analytical techniques should be employed.

  8. Evaluating Pyrogen Contamination Risk And MAT In Pharmaceutical Processing

    The measurement of pyrogens is an important safety measure for parenterally administered drugs. Here, we explore several advantages the Monocyte Activation Test (MAT) provides over the rabbit pyrogen test.

  9. Progress In LC-MS-Based Metabolomics Techniques

    Get updated on recent and current advances in metabolome analysis by mass spectrometry with this introduction to the different approaches and technologies.

  10. Neutralizers Of Disinfectants In Culture Media

    This study investigates the efficiency of disinfectant-neutralizing agents added to culture media in the presence of several commercially available disinfectants.