Package Inspection White Papers & Case Studies

  1. Contract Packaging Organization Installs Checkweigher To Solve Accuracy Challenges 6/18/2012

    Quality Packaging Specialists, Inc., a custom contract packing company, thrives in a crowded market by providing high quality production, responsive service and competitive prices. By Kyle Thomas, Mettler-Toledo Hi-Speed

  2. Checkweigher Provides High-Throughput Tube Line Automation Inspection 6/15/2020

    Teligent produces a range of generic prescription topical and injectable pharmaceuticals. To automate inspection on their high-throughput tube line, they turned to a dual-lane checkweigher.

  3. A Holistic Strategy To Ensure Container Closure Integrity Of Sterile Injectable Vial Product 1/25/2021

    Recent regulatory guidance has triggered changes in industry best practices in the area of container closure integrity testing (CCIT). However, assuring good CCI of sterile injectable product goes beyond CCI testing. A more science-based holistic approach that includes robust design & qualification of the process and the implementation of appropriate process controls is required. This article describes a framework enabling such a holistic approach to CCI that assures both the primary packaging and the process contribute to good CCI of sterile injectable vial product.

  4. Sterile Production Process Studies Using 100% Headspace Inspection Of Finished Product 12/27/2018

    This app note describes the application of the PULSAR inspection platform to perform 100% headspace oxygen monitoring during the filling of oxygen-sensitive formulations, 100% container closure inspection of suspect batches, moisture inspection of freeze dried product, and automated media fill inspection.

  5. Container Closure Integrity Testing Of IV Bags

    As a means to ensuring the safety of sterile products, the FDA and the United States Pharmacopeia have provided strict guidelines for the testing of container closure systems.

  6. Extractables And Leachables: Risk Management And Analytical Solutions 10/11/2023

    Partnering with a CDMO that offers comprehensive and robust E&L studies can help facilitate a smooth product launch by ensuring minimal impact from impurities, all while mitigating risks.

  7. Case Study: Pharmaceutical CMO Uses X-Ray, Metal Detection And Checkweigher Systems To Achieve High Quality Standards 8/11/2011
    Pharma Tech Industries (PTI), a contract manufacturer and packer of pharmaceuticals, medical devices and personal care products, is focused on exceeding customers’ expectations. To consistently achieve their high quality standards, they rely on x-ray and metal detection systems from Mettler-Toledo Safeline and checkweighers from Mettler-Toledo Hi-Speed.
  8. Correlating Stopper Height To Container Closure Integrity 11/21/2023

    Learn how to comply with the new EU Annex 1 Section 8.28. Here, we describe a typical raised-stopper investigation and demonstrate how to generate scientifically robust data using headspace analysis.

  9. Comparing The LFS Machine To The Methylene Blue Dye Test For Leak Testing Blister Packs 6/16/2008

    Application Note: Comparing The LFS Machine To The Methylene Blue Dye Test For Leak Testing Blister Packs

  10. Utilizing A Checkweigher To Identify Inaccurately Filled Products 6/9/2020

    Sanofi-Aventis uses checkweighers to check vital insulin: in the Injectables Division, where liquid drugs such as different types of insulin or drugs for emergency medicine are produced, the packaged medical compounds are subjected to final checks using a dynamic checkweigher.