Package Inspection White Papers & Case Studies

  1. Rapid Nondestructive Moisture Determination Of Freeze-Dried Product 12/28/2018

    Rapid water vapor determination with an optical method could replace the slow destructive traditional methods for the moisture analysis of freeze-dried product. A description of industry applications of headspace moisture analysis including freeze drying cycle optimization, lyo chamber moisture distribution mapping, and 100% moisture inspection of commercial freeze-dried product.

  2. Smoke Signals – One Plant's Secret For Assuring Aseptic Control 11/29/2018

    Airflow visualization testing, conducted as part of a routine review program, can help assure that aseptic filling areas remain under a state of proper control.

  3. Non-Destructive Options For Leak Testing Blister Packages

    Concerns about waste, human error, and cGMP compliance are leading some packaging facilities to seek alternatives to the standard blue-dye leak test for blister packaging.

  4. Help Keep Pharmaceuticals Safe: Metal Detection Overview And Guidelines

    Although metal detection has been in use to identify the presence of ferrous, nonferrous, or stainless-steel contaminants for decades in the pharmaceutical industry, it has not been widespread.

  5. Achieving Container Closure Integrity During Cryogenic Storage Conditions Using An Optimized Vial Stopper Combination 2/17/2022

    Here, we investigate possible primary packaging solutions for therapies requiring even colder storage temperatures down to cryogenic levels (-150°C to -180°C).

  6. Test Method Development For A Container Closure Integrity Test Using Headspace Gas Ingress 3/11/2021

    To ensure patient safety, good container closure integrity (CCI) is of great importance for all sterile injectable products. Recent regulatory guidance has made clear that there is no ‘gold standard’ for CCI testing. As a CCI test method, headspace analysis is based on detecting changes in the headspace gas composition that result from gas ingress through a leak. Non-destructive headspace analysis, using laser-based spectroscopy, can be used to directly quantify the gas concentration inside a sealed parenteral package. It can be applied to a range of product configurations, and formulations, and has historically been used for detecting leak defects in modified headspace product.

  7. How To Maximize The Performance Of Your Metal Detector 2/7/2019

    To get the most out of your metal detection program, it’s important to understand the factors that affect metal detector sensitivity and the ability to find different types of metal. This guide explains the various elements.

  8. OEE And Product Inspection 2/13/2025

    Explore the calculation of Overall Equipment Effectiveness (OEE) and the impact of product inspection equipment on OEE in the pharmaceutical industry.

  9. Headspace Moisture Analysis For Determination Of Residual Moisture Content In Lyophilized Pharmaceutical Products 8/24/2021

    Here, we describe how rapid non-destructive headspace moisture determination enables the generation of insightful data for product life cycle activities.

  10. The Importance Of Package Integrity To Shelf Life Of Products 6/9/2020

    Pharma Tech Industries, a contract manufacturer and packer of pharmaceuticals and medical devices relies on x-ray, metal detection systems, and checkweighers to achieve their high quality standards