Production Featured Articles
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Scalable AAV Purification Process For Gene Therapy
11/22/2021
Processes to produce a common viral vector for gene therapy – adeno-associated virus (AAV) – are in place, but there’s room to improve them. In this article, we focus on optimizing AAV purification to achieve high overall yields and efficiently remove empty capsids and other impurities.
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Boost Performance With A Chromatography Resin Update
11/18/2021
Although workhouse resins developed in the 1980s are still used in many processes worldwide, you could be missing out on better productivity and performance. Find an answer to the question, "How do I know which modern resin to use in my new projects?"
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Mechanistic Modeling For Downstream Processing: Digital Twins Are Here To Stay
11/17/2021
Expensive and time-consuming laboratory experiments, iterative empirical optimization, and even statistical methods alone are not the answers to the challenges of the future. Many global biopharma companies are working on establishing digital twins of their upstream or downstream processes.
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Biologics Development, Manufacturing & Packaging Roundtable
11/16/2021
A panel of experts discussed challenges and opportunities related to the development, clinical phases, and commercialization of biologics. They also offered insights on how to improve sponsor-CDMO relationships.
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Selecting A CMO Partner For Sterile Injectable Manufacturing
11/10/2021
Performing the transfer of a product or technology from a small-scale development process to full-scale commercial manufacturing can be difficult, but vetting for the right CMO partner can pose its own challenges.
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Training Devices And Patient Education Play A Crucial Role In The Self-Injection Drug Delivery Market
11/8/2021
Understand the role training devices and patient education play with regard to self-injection therapies. Review the evolution of injection devices and prefilled syringes, the benefits of training devices combined with patient education, and an empirical look at patient training.
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Where Is Technological Innovation Needed For CAR-T Manufacturing?
10/29/2021
Investment in cell therapy biomanufacturing has continued to follow a steady upward trend. Even with the anticipated increases in capacity, there are still concerns facing current and future cell therapy manufacturing capacities, including an anticipated “capacity crunch.” This article examines where technological innovation is needed to avoid this capacity crunch.
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The Need For AI/ML In Drug Discovery, Dev, & Clinical Trials
10/25/2021
While an influx of new companies and technologies is spurring innovation in the industry, these startups are increasingly in competition for talent and capital. Although a fairly new area with respect to the use of AI, the drug design and development process is ripe for the application of machine learning and deep learning techniques.
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Do Strategic Partnerships Meet Outsourcers Expectations?
10/18/2021
ISR’s CDMO Outsourcing Models report dives into three approaches to contracting manufacturing work, the motivations behind them, and which methods earn the greatest satisfaction among users.
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COVID-19 Spurs Growth Of China’s Domestic Bioprocessing Suppliers
10/8/2021
Just as the U.S. and European bioprocessing supply systems have seen more robust growth than ever before, China’s domestic demands for single-use bags, cell culture media, and purification resins are all on the rise. BioPlan’s Top1000Bio database of global bioprocessing facilities has tracked industry capacity and employment growth over 15 years.