Insights On Pharmaceutical Production

  1. How To Select An API Partner For Strategic Success 8/11/2020

    A strategic partner should always seek ways to innovate and improve your compound or product’s value, and do it with the dedication of a partner, not a supplier. With the growing importance of contract services and plenty of providers, it is more critical than ever to make the right choice. Where do you start? Tom Wilson, Pfizer CentreOne’s Contract Manufacturing Lead shares his tips for picking the perfect API partner.

  2. Ensuring Strength And Flexibility Of Single-Use Bags In All Applications 3/18/2019

    The costs are high when leakage occurs during steps that are critical to patient safety. Read how the robustness of Sartorius films makes them safe and easy to use for all process steps and applications.

  3. Technical Considerations For Developing Oral Solids (Part 2) 8/3/2020

    What technical considerations should be at the forefront for your oral solids project? This two-part series features four oral solids experts from Pfizer CentreOne’s global network and partner organizations discussing the technical considerations to be aware of. In the second installment of the series, our experts consider the effects of equipment design and different tablet strategies.

  4. Grifols New Manufacturing Facility Provides Contract Development And Manufacturing Solutions For Recombinant Proteins 5/3/2019

    Grifols' Consolidated Manufacturing Facility (CMF) is a flexible, multiproduct facility with available manufacturing capacity that created an opportunity to leverage their existing technical expertise and commitment to quality to provide contract services to biopharma companies as a recombinant protein CDMO and support the development of innovative therapies. We recently spoke with Paul Magreta at Grifols about their new $80 million manufacturing facility in Emeryville, California, and the CDMO Services they offer. 

  5. Overcoming Mixing And Blending Problems In Ophthalmic Manufacturing Operations 1/6/2021

    Contact lense solutions tend to have a similar base formulation: a saline solution (typically 5%) with a range of added ingredients according to the desired function. These include thickening agents, surfactants and active ingredients. Preparing saline solutions is a fairly simple task however stabilizers tend to form agglomerates which cannot be broken down by agitation and long mixing times are required to fully hydrate and dissolve the solids.

  6. Effectively Managing Data In Process Development 1/11/2021

    Addressing data management challenges during drug development calls for a deeper understanding of the shortcomings of today’s methods and the factors you need to consider when adopting a solution to overcome them.

  7. Viral Clearance: The Basics On How To Conduct Effective Studies 5/17/2019

    Effective viral clearance studies remain one of the challenges facing manufacturers of biologics. These studies are an essential part of process validation and are critical to ensure drug safety. This article provides the basics of what you need to know when studying virus reduction of a chromatography step.

  8. Particle Engineering For Inhalation Drug Delivery 10/6/2020

    Inhalation-based drug products play a critical role in addressing the rising incidence of respiratory diseases around the globe. Particle engineered-based formulations are key in designing and developing effective dry powder inhaler (DPI)-based drugs. This article discusses key parameters for choosing the right particle engineering approach to meet DPI target product profiles.

  9. A Model To Increase Yield In mAb Cell Culture Perfusion At Large Scale 9/28/2020

    As process intensification is adopted into large scale manufacturing, the responsibility of scale-down models to accurately represent the expanded operating space quickly follows. 

  10. Deagglomerating When Mixing Powders And Liquids 1/8/2021

    When adding powders to liquids they have a tendency to form agglomerates which conventional agitators cannot readily break down. The high shear action of the Silverson rotor/stator workhead rapidly disperses agglomerates, exposing increasing areas of the solid to the surrounding liquid.