Solid Dose Manufacturing Solutions

  1. Virus Screening And HPAPI Handling With A Continuous Process Isolator 3/11/2021

    The Analytical Process Isolator™ or A.P.I. is a continuous process isolator to vented enclosure system that allows for ISO 5 clean processing and intake or outtake through a negative pressure vented cabinet.

  2. Oral Solid Dose Formulation Assessment Services 1/31/2024

    Send a test sample of your powder to Natoli Scientific to get your formula characterized following USP <1062> Guidelines (Tablet Characterization Methods) that we have been practicing for over 25 years.

  3. Aseptic Pharmaceutical Isolators From Franz Ziel 9/24/2024

    Isolators with product protection as a housing for aseptic processes, e.g., filling, loading and unloading of freeze dryers.

  4. Used Sejong 15 Station Phamaceutical Tablet Press 2/23/2023

    Used Sejong rotary tablet press, model GRC-15C, 15 station, D tooled, 6 kn main compression, 2 kn pre compression, 25 mm max tablet diameter, 22 mm max depth of fill, with feed hoppers, rated up to 67500 tablets/hour, with integrated controls and touchscreen interface, serial# ST17866, built 2017.

  5. Flow Sciences Compounding Pharmacy Enclosures 6/24/2019

    The Flow Sciences vented enclosure is essential to protect your health and ensures safety by containing powder and virtually eliminating exposure to potent powders.

  6. Powder Flow Properties & Characterization Services 1/31/2024

    Basic Powder Flow Characterization [USP <1174>]:

    A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

    Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

    When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

  7. Used Thermo Scientific Haake Pelletizing Line: Pharma 11 HME 5/30/2025

    Used ThermoScientific Haake Pelletizing line, with model Phama 11 HME twin screw extruder, item# 553-0020, co-rotating screws, 40:1 l/d, 1000 rpm screw speed, 1.5 kw motor drive, with feeder, and operator HMI touchscreen. ThermoScientific Ph11 Conveyor, item# 553-0600, serial# 1-21004125001. ThermoScientific pelletizer, 6 blade rotor with pull roll, 230 volt, CE design, extruder machine# KU18-000011, serial# 1-1800319001, built 2019.

  8. Production-Scale Pharmaceutical Filling Systems 5/14/2021

    Dec‘s philosophy is to develop customer-specific modules and equipment. Starting with agreed project scope, intensive brainstorm sessions, strong design processes and (customer) reviews, the aim is to deliver an innovative filling solution. During the concept development, risk analysis is an important tool in the decision-making process.

  9. Powder Discharging Systems For Non-Potent To High Potent Active Ingredients 8/7/2020

    The big bag emptying stations of Dec are based on a modular design. This allows to be ideally equipped with systems for each product’s characteristics with corresponding docking systems for non-potent to highly active powders. Depending on the product flow, there is a range of discharge devices or lump breakers available. With the use of load cells, it is possible to dose accurately into the receptacle.

  10. Pharmaceutical Freeze Dryer Cryodesiccation Suite 6/24/2019

    The Lyophilizer Cryodesiccation Suite designed to provide personnel protection while working with powder substances. Designed to work with a lyophilizer with dimensions 450mm (L) x 450mm (W) x 450 mm (H) (17.72” L x 17.72” W x 17.72” H).