Featured Articles

1. PCR Diagnostic Kits & Freeze-Drying Considerations 3/2/2021

   Polymerase chain reaction (PCR) is a method widely used in molecular biology to make many copies of a specific DNA segment. There are numerous processing challenges with the PCR method including that the components require refrigeration and they have a relatively short shelf life and cross contamination is a concern. Learn more about technologies and products available to help overcome these challenges.

2. Addressing Challenges Of Ophthalmic Product Filling 2/10/2021

   Many innovative pharmaceutical packaging formats are being developed to meet the growing requirement for sterile, safe and secure packaging and delivery of ophthalmic products. Due to the diversity of these sterile ophthalmic medications, aseptic filling lines must be highly sophisticated and adaptable to address a variety of packaging challenges in this growing market.

3. Robotic Aseptic Processing For Filling Ready-To-Use (RTU) Vials, Syringes And Cartridges 2/10/2021

   As patient treatments move away from broad population therapies in favor of the targeted treatment of smaller (personalized) patient populations, the biopharmaceutical industry is transitioning to smaller aseptic batch manufacturing processes. Robotic solutions provide pharmaceutical manufacturers with a faster, more flexible and cost-effective way to fill different container formats using the same filling platform, responding to the growing demand for small batches, customized packaging, rapid product and format changeovers along with a less user intervention during the filling process.

4. Myth Busting: Misconceptions In Lyophilization 12/3/2020

   Several assumptions based on previous knowledge or experience regarding lyophilization are often made but as with many techniques that have become well-developed over time, there remains a number of misconceptions that persist in this process. This tech note summarizes both webinars and includes a selection of questions from the Q&A sessions from a two-part series of webinars questioning ten assumptions that are made when developing the freezedrying process for pharmaceutical products and how these may be counteracted.

5. Accelerated Probe And Primer Production To Enable COVID-19 Testing With The SP Genevac HT Series 3i Evaporator 8/25/2020

   As the novel coronavirus (COVID-19) pandemic is progressing throughout 2020, it has become evident that millions of testing kits are needed internationally every single day. This article explores how a leading provider of tools and technologies for genetic analysis, LGC, Biosearch Technologies, is aiding in the fulfilment of this demand, assisted by evaporation technology from SP Genevac.

6. Using Parallel Evaporators To Escalate COVID-19 Test Kit Preparation 8/25/2020

   An issue for all countries now is how to obtain a sufficient supply of COVID-19 testing kits, when the international demand for them has never been higher. As laboratories around the world scale up their production of PCR test kits to aid the global fight against the virus, improvements to the workflow for producing testing kits are urgently needed to increase the efficiency of test kit production. Centrifugal evaporators offer an ideal solution to improving the efficiency of test kit production.

7. Drug Discovery Workflow For PROTAC With A Focus On Eliminating Bottlenecks In Evaporation 8/25/2020

   An emerging modality of therapeutics called PROteolysis TArgeting Chimeras (PROTACs) could enable the design of new drugs targeting “undruggable” proteins, which make up to 85% of the proteome. This article introduces PROTACs and the benefits they can offer to the drug discovery field, before discussing how the issues with their synthesis can be overcome.

8. Putting Fill-Finish Customization Into Your Line Of Sight 8/25/2020

   There is a growing need for a complete package of rapid product development tools and scalable, good manufacturing (GMP) compliant, aseptic fill-finish production lines optimized for small batch applications. This article discusses the development and manufacturing challenges, and highlights the key considerations required when evaluating product development tools, selecting equipment, and optimizing small batch fill-finish lines.

9. ControLyo - What Can It Do For Your Business? 8/6/2020

   SP takes you on a visual case for increased profitability, batch homogeneity, and shorter run times during commercial lyophilization using controlled nucleation. Here, you will see how controlled nucleation can make your scale up seamless.

10. SP Hull Versa-Line Fill-Finish Solutions 8/6/2020

    The SP modular Versa-Line fill-finish system and Line of Sight™ freeze dryer tools, technologies and equipment provide product development and configurable full line solutions.