Containment & Isolation Feature Articles

1. Reducing Bioburden Risks In Aseptic Manufacturing 8/11/2017

   Manufacturers can benefit from this alternative transfer technology that has now been adapted to solve issues in aseptic handling.

2. How To Prepare For Chamber Mapping In Life Sciences — 8 Critical Steps 7/17/2017

   A failed chamber mapping study can lead to unnecessary costs in valuable biopharmaceutical production time or regulatory and product quality issues.

3. Aseptic Production Automation To Reduce Risk And Cost 10/21/2015

   This article discusses how to apply current isolation technologies with robotic systems to reduce the risk of microbial contamination in aseptic processes caused by human intervention.

4. Increase In HPAPI Manufacturing Highlights Need For Containment And Isolation Systems 7/21/2015

   An estimated 25 percent of globally manufactured drugs contain highly potent active pharmaceutical ingredients (HPAPIs). HPAPI drugs, which include small-molecule and biologic compounds as well as antibodydrug conjugates (ADCs), are often used in the treatment of cancer. The fastest growing segment of the HPAPI market are ADCs, a new class of therapeutic agents that deliver cytotoxic drugs selectively to antigen-expressing tumor cells. Non-oncology HPAPI compounds include hormones, narcotics, and retinoids.

5. The Answer To Final Pack Off Containment 2/27/2007

   The DoverPac® continuous liner system provides the advantage of replacing packs without breaking containment, unlike using inflatable heads or having operators shuffle tube stock.

6. Flexible Containment Solutions Guide: Mill Containment System - Jet Mills

   The process for this application consists of the controlled feeding of a mill through a feeder. The powder is introduced into the feeder using a drum transfer system.

7. Key Considerations When Purchasing Your Biological Safety Cabinet

   The purchase of a biological safety cabinet should be made with much consideration. These cabinets serve as the Primary Engineering Control as the first line of defense in providing personnel, environmental and/or product protection against biohazards and potentially harmful agents in a range of laboratory, research, clinical and industrial settings.

8. Sterile Drug Manufacturing Techniques: Key Benefits To Know

   Although pharma manufacturers take stringent steps to ensure their production systems are as safe as possible, a fully gowned operator can still create as many 150,000 particles per minute.

9. Emerging Gloveless Robotic Technologies In Aseptic Manufacturing For Personalized Cytotoxic Drugs

   The blockbuster-model that was driving the pharmaceutical manufacturing industry in the last several decades has almost ended. Massive production, large batches, high speed lines have been designed to supply the patients with “multipurpose” small molecules drugs to cover the huge worldwide demand of health for the most common diseases. The next generation drugs will focus on the single patient and bespoke to cover the individual health demand. For instance, biotech products and large molecules are the most promising therapeutic means for treatment of different kinds of cancer. By Sergio Mauri, Manager, BU Integrated Projects, Fedegari Group

10. Investigation Of New Level Technologies In Single Use, Disposable Systems

    This article presents guided wave radar level measurement as an acceptable, less expensive alternate to load cell systems. By David Ladoski and Dan Klees