MilliporeSigma Application Notes & White Papers
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Improving API Solubility Using Hot Melt Extrusion Formulation
2/27/2025
Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.
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Monitoring Microbial Contamination Of Mammalian Cell Cultures
2/21/2025
Mammalian cells are widely used to produce complex processed molecules. Explore a system that effectively detects microbial contamination in mammalian cell cultures and utilizes a newly formulated lysis buffer.
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Integrating Phase — Appropriate Quality Standards
12/9/2024
Phase-specific quality standards in biopharmaceuticals ensure GMP compliance, and maintain data integrity. Experienced CDMOs help balance quality expectations with accelerated development timelines.
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Improving Bioprocess Monitoring And Control With Multivariate Data Analysis
12/9/2024
Learn about multivariate data analysis (MVDA) techniques, like PCA and PLS, that enable near real-time monitoring, prediction, and optimization of biomanufacturing processes.
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Evaluation Of Extractables And Physical Compatibility Of The Mobius® ADC Reactor Single-Use Components For ADC Manufacturing
10/29/2024
Explore study results evaluating the physical compatibility of single-use components in the Mobius® ADC Reactor and the level of extractables when exposed to dimethyl sulfoxide and dimethyl acetamide.
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Performance Of Mobius® Bag Assemblies With Ultimus® Film In Truck Shipping Simulation Test
10/29/2024
Explore findings from a study testing Mobius® single-use bags under rigorous shipping conditions, demonstrating the suitability for transporting various liquid volumes while preserving their integrity.
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Mobius® ADC Reactor Performance
10/22/2024
Learn about a family of single-use ADC reactors that has been developed to offer a safer and more efficient ADC production method than traditional mixing systems and meet the industry's growing needs.
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Accelerating Bulk Harvest Release Testing With A PCR-Based Solution
7/3/2024
Adventitious agent testing is frequently a bottleneck in downstream processing. Discover a PCR-based solution for manufacturing processes using CHO cells and animal origin-free components.
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Sterility Testing Of Products With Antimicrobial Properties
6/4/2024
Drugs formulated with antibiotics, preservatives, or other chemicals may inhibit microbial viability and growth. Learn more about three golden rules to be effective against antimicrobial effects.
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Sterility Testing Of Products To Be Diluted In Isopropyl Myristate
6/4/2024
Discover one possible test set-up to dilute a product in isopropyl myristate, filter it, and rinse the membrane to eliminate residues that may inhibit microbial growth.