MilliporeSigma Application Notes & White Papers

  1. Improving API Solubility With Mesoporous Silica 6/5/2025

    Poor solubility of active pharmaceutical ingredients can hinder drug effectiveness. Learn how innovative formulation strategies enhance solubility and bioavailability to improve therapeutic outcomes for challenging drug candidates.

  2. Improving API Solubility Using Spray Drying With Polyvinyl Alcohol 6/5/2025

    Enhancing the solubility of poorly soluble APIs is vital for improving bioavailability and therapeutic outcomes. Discover how advanced formulation techniques like hot-melt extrusion and spray drying can overcome this challenge.

  3. API Solubility And Dissolution Enhancement Via Formulation 6/4/2025

    Solubility and dissolution rate of an API are essential for effective oral drug absorption. Discover how these factors directly influence bioavailability, which determines how much and how quickly a drug enters circulation.

  4. Advantages Of Spray-Dried Mannitol In Roll Compaction 4/2/2025

    Pharmaceutical excipients like mannitol enhance formulation stability, flowability, and compressibility, which are crucial for robust tablets. Read how these properties improve patient compliance.

  5. Improving API Solubility Using Hot Melt Extrusion Formulation 2/27/2025

    Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.

  6. Monitoring Microbial Contamination Of Mammalian Cell Cultures 2/21/2025

    Mammalian cells are widely used to produce complex processed molecules. Explore a system that effectively detects microbial contamination in mammalian cell cultures and utilizes a newly formulated lysis buffer.

  7. Integrating Phase-Appropriate Quality Standards 12/9/2024

    Incorporating phase-specific quality standards ensures GMP compliance throughout biopharmaceutical development. Collaborating with an experienced CDMO addresses late-stage quality needs and efficiently manages accelerated product development timelines.

  8. Improving Bioprocess Monitoring And Control With Multivariate Data Analysis 12/9/2024

    Learn about multivariate data analysis (MVDA) techniques, like PCA and PLS, that enable near real-time monitoring, prediction, and optimization of biomanufacturing processes.

  9. Evaluation Of Extractables And Physical Compatibility Of The Mobius® ADC Reactor Single-Use Components For ADC Manufacturing 10/29/2024

    Explore study results evaluating the physical compatibility of single-use components in the Mobius® ADC Reactor and the level of extractables when exposed to dimethyl sulfoxide and dimethyl acetamide.

  10. Performance Of Mobius® Bag Assemblies With Ultimus® Film In Truck Shipping Simulation Test 10/29/2024

    Explore findings from a study testing Mobius® single-use bags under rigorous shipping conditions, demonstrating the suitability for transporting various liquid volumes while preserving their integrity.