MilliporeSigma Application Notes & White Papers

1. Improving API Solubility Using Hot Melt Extrusion Formulation 2/27/2025

   Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.

2. Monitoring Microbial Contamination Of Mammalian Cell Cultures 2/21/2025

   Mammalian cells are widely used to produce complex processed molecules. Explore a system that effectively detects microbial contamination in mammalian cell cultures and utilizes a newly formulated lysis buffer.

3. Integrating Phase — Appropriate Quality Standards 12/9/2024

   Phase-specific quality standards in biopharmaceuticals ensure GMP compliance, and maintain data integrity. Experienced CDMOs help balance quality expectations with accelerated development timelines.

4. Improving Bioprocess Monitoring And Control With Multivariate Data Analysis 12/9/2024

   Learn about multivariate data analysis (MVDA) techniques, like PCA and PLS, that enable near real-time monitoring, prediction, and optimization of biomanufacturing processes.

5. Evaluation Of Extractables And Physical Compatibility Of The Mobius® ADC Reactor Single-Use Components For ADC Manufacturing 10/29/2024

   Explore study results evaluating the physical compatibility of single-use components in the Mobius® ADC Reactor and the level of extractables when exposed to dimethyl sulfoxide and dimethyl acetamide.

6. Performance Of Mobius® Bag Assemblies With Ultimus® Film In Truck Shipping Simulation Test 10/29/2024

   Explore findings from a study testing Mobius® single-use bags under rigorous shipping conditions, demonstrating the suitability for transporting various liquid volumes while preserving their integrity.

7. Mobius® ADC Reactor Performance 10/22/2024

   Learn about a family of single-use ADC reactors that has been developed to offer a safer and more efficient ADC production method than traditional mixing systems and meet the industry's growing needs.

8. Accelerating Bulk Harvest Release Testing With A PCR-Based Solution 7/3/2024

   Adventitious agent testing is frequently a bottleneck in downstream processing. Discover a PCR-based solution for manufacturing processes using CHO cells and animal origin-free components.

9. Sterility Testing Of Products With Antimicrobial Properties 6/4/2024

   Drugs formulated with antibiotics, preservatives, or other chemicals may inhibit microbial viability and growth. Learn more about three golden rules to be effective against antimicrobial effects.

10. Sterility Testing Of Products To Be Diluted In Isopropyl Myristate 6/4/2024

    Discover one possible test set-up to dilute a product in isopropyl myristate, filter it, and rinse the membrane to eliminate residues that may inhibit microbial growth.