MilliporeSigma Application Notes & White Papers

  1. Accelerating Bulk Harvest Release Testing With A PCR-Based Solution 7/3/2024

    Adventitious agent testing is frequently a bottleneck in downstream processing. Discover a PCR-based solution for manufacturing processes using CHO cells and animal origin-free components.

  2. Sterility Testing Of Products With Antimicrobial Properties 6/4/2024

    Drugs formulated with antibiotics, preservatives, or other chemicals may inhibit microbial viability and growth. Learn more about three golden rules to be effective against antimicrobial effects.

  3. Sterility Testing Of Products To Be Diluted In Isopropyl Myristate 6/4/2024

    Discover one possible test set-up to dilute a product in isopropyl myristate, filter it, and rinse the membrane to eliminate residues that may inhibit microbial growth.

  4. Overcoming The Solubility Challenges Of Antibody-Drug Conjugates 6/3/2024

    Discover a chito-oligosaccharide that significantly improves the solubility of antibody-drug conjugates (ADCs) when included in the linker-payload construct.

  5. Comparative Study On Secondary Contamination Risk 1/31/2024

    Accurate testing results are crucial for product safety. Explore the findings of a comparative study evaluating two different platforms for the membrane filtration of microorganisms in quality control.

  6. Testing Cell-Based Immunotherapeutics For Microbial Contaminants 10/23/2023

    In this study, two different immune cell preparations were evaluated for their compatibility with the Milliflex® Rapid System to establish a USP and EP compliant method for rapid sterility testing.

  7. Detection Of Low Bacterial Contamination From Neoprene® Gloves With ICR Swabs 9/22/2023

    This study was designed to prove the suitability of ICR Swabs and lockable TSA w. LTHThio contact plates to detect low numbers of different bacterial test strains from Neoprene® gloves.

  8. Detection Of Low-Level Bacterial Contamination Using ICR Swabs And Contact Plates 9/22/2023

    Contact plates and swabs are commonly used for surface monitoring in aseptic manufacturing. Here, we demonstrate the recovery rates of MilliporeSigma’s ICR Swabs and lockable TSA w. LTHThio contact plates.

  9. How To Use MAS-100® Air Samplers With BioTrends EM® System 9/22/2023

    Environmental monitoring plays an important role in pharmaceutical manufacturing contamination control. Learn how MilliporeSigma and the BioTrends EM® software system pair together for your data analytics.

  10. Implementing High Cell Density Cryopreservation In Your Seed Train 1/22/2023

    Simplify seed train intensification with high cell density cryopreservation. Eliminate the need for manual scale-up steps and enable risk reduction through closed banking and inoculation processes.