Natoli Products

  1. Pharmaceutical Capsule Polisher 5/6/2024

    When it comes to your capsules, cleanliness is key. That’s why this revolutionary polisher guarantees that all areas of the polisher are easy to clean. The one-piece cylindrical polishing chamber promotes powerful, cyclonic air flow ensuring continuous movement and ease of cleaning.

  2. Powder Flow Properties & Characterization Services 1/31/2024

    Basic Powder Flow Characterization [USP <1174>]:

    A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

    Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

    When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

  3. Oral Solid Dose Formulation Assessment Services 1/31/2024

    Send a test sample of your powder to Natoli Scientific to get your formula characterized following USP <1062> Guidelines (Tablet Characterization Methods) that we have been practicing for over 25 years.

  4. Oral Solid Dose Formulation And Lab Scale Capabilities 1/31/2024

    Natoli Scientific is dedicated to developing high-quality affordable products for your market needs.

    We provide a formulation design based on a strong scientific understanding and decoding interplay of materials and process parameters to ensure product integrity. We use traditional as well as principles of ‘Quality by Design (QbD)’ to develop robust lead prototype formulations. The early sound scientific investment in product development saves time and money during scale-up and commercial manufacturing.

  5. OSD Pharmaceutical Tablet Manufacturing Services For Clinical Trials 1/31/2024

    Natoli Scientific offers manufacturing services of oral solids at a pilot scale and drug products for clinical trials.

    We also offer full-scale commercial manufacturing service till you are ready with your own manufacturing facility to avoid delay in the commercial launch.

    Team Natoli understands the complexity of the tablet manufacturing process over more than half a century. We are ready to shoulder every step of the tablet manufacturing chain from blending to granulation, to milling, to compression, to coating. Our manufacturing capabilities are backed up by our expert scientific team, who are ready to offer guidance in product development, technical transfers, and scale-ups.

  6. Pharmaceutical Preformulation Support Services 1/31/2024

    Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.

    Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.

  7. Oral Solid Dose Formulation Troubleshooting Support Services 1/31/2024

    Natoli organization is a reputed leader with more than a half century experience in the tablet manufacturing technology.

    We understand tablets better. We are here for serving your needs to overcome challenges associated with commercial manufacturing of solid dosage forms across the globe (North America, Europe, Asia).

    Our Natoli scientific team uses holistic approach to understand and solve important tableting problems like capping, lamination, picking, and sticking. We integrate scientific information gathered at material, process, and instrument level to understanding and decode root causes of these common tableting issues.

  8. Pharmaceutical Tablet Presses 1/31/2024

    Natoli’s line of affordable tablet presses is designed, engineered, and manufactured in the U.S.A. and built on our decades of experience in the tableting industry. We know our customers want presses that efficiently meet their R&D and/or production needs.

    With Natoli you have a choice in your tablet press: R&D or production, single-station or rotary, fully automated or manual. Whatever your need, Natoli’s best-in-class tablet presses can help you optimize tablet quality while saving time and reducing costs.

  9. Pharmaceutical Double-Sided Rotary Tablet Press 3/30/2023

    INCREASED PRODUCTION RATE AND BETTER YIELDS=EFFICIENCY
    The NP-155 pharmaceutical tablet press is equipped with essential features that were designed and engineered to produce quality tablets at an affordable price. With its double-sided design, the NP-155 pharmaceutical tablet press produces two tablets per press turret cycle, allowing you to double your tablet production while running at standard single-sided rotary press speeds. The NP-155 provides significant versatility for delivering exceptional tablet quality, consistency, and production.

  10. Control Software For Production Tablet Presses: AIM™ Pro Plus 10/18/2019

    AIM™ Pro Plus Control System Makes Tablet Production Easy
    The Natoli AIM™ Pro Plus control system is a flexible software and hardware architecture that is standard on Natoli production tablet presses. This industry-leading package can be retrofitted to almost any production tablet press to increase production, improve tablet consistency, and provide an easier-to-manage production environment.