Package Inspection White Papers & Case Studies

1. Helium Leak Detection And Vial Crimp Force Measurements 12/1/2022

   A global pharmaceutical equipment entity was interested to see how various levels of crimping force in vials affect helium leak rate data. Explore the results obtained from this case.

2. Helium Leak Detection On Glass Cartridge Containers 1/5/2026

   Helium leak detection offers unmatched sensitivity for verifying glass cartridge seal integrity. Learn how this advanced method outperforms traditional tests and provides confidence in packaging.

3. Container Closure Systems For Packaging Human Drugs And Biologics 7/28/2011

   This document is intended to provide guidance on general principles for submitting information on packaging materials used for human drugs and biologics. This guidance is not intended to describe the information that should be provided about packaging operations associated with drug product manufacture. By PharmaSystems, Inc.

4. Development Of A Container Closure Integrity Test Method For Autoinjectors 9/30/2024

   Explore how a non-destructive method can be developed to test container closure integrity in autoinjectors equipped with an optically transparent window.

5. Optimized Product Recovery Using The Drug Product Filtration System 1/12/2026

   Explore strategies to maximize drug product recovery during sterile filtration, minimize hold-up volume, and reduce dilution after PUPSIT to ensure higher yield, improved efficiency, and less waste.

6. Checkweighers: Using Data To Minimize Expensive Product Giveaways 7/14/2017

   Making sure final product weight is within acceptable min/max ranges is a critical manufacturing objective for F&B companies. This article details how checkweighers help ensure proper fill levels.

7. Correlating Stopper Height To Container Closure Integrity 11/21/2023

   Learn how to comply with the new EU Annex 1 Section 8.28. Here, we describe a typical raised-stopper investigation and demonstrate how to generate scientifically robust data using headspace analysis.

8. Ensure Quality Control With Innovative Software 7/1/2025

   Ensure unmatched product quality with an X-ray system paired with an innovative software that detects contaminants and missing items in stacked packaged goods with precision.

9. The Benefits Of Package Integrity Testing

   In a world full of hungry microorganisms, it is critical that medical devices, designed to heal, do not inadvertently do the opposite by infecting the patient. To prevent infection, a device’s packaging or “sterile barrier system” must maintain sterility over the product’s entire shelf-life. By Ed Emerson

10. Detecting Integrity Breaches In A Range Of Pharmaceutical Blister Package Types

    Demonstrating the integrity of pharmaceutical blister packs is critically important, as any defects can affect the shelf life and efficacy of the contents. By Dr. D. Dixon, University of Ulster