Package Inspection White Papers & Case Studies

31. Achieving Container Closure Integrity During Cryogenic Storage Conditions Using An Optimized Vial Stopper Combination 2/17/2022

    Here, we investigate possible primary packaging solutions for therapies requiring even colder storage temperatures down to cryogenic levels (-150°C to -180°C).

32. Headspace Moisture Analysis For Determination Of Residual Moisture Content In Lyophilized Pharmaceutical Products 8/24/2021

    Here, we describe how rapid non-destructive headspace moisture determination enables the generation of insightful data for product life cycle activities.

33. Inspecting On The Edge — Understanding Punch Tip Wear 7/30/2024

    Why is a horizontal optical comparator highly recommended for tablet manufacturers as a measuring tool for punch tip inspection, and what strategies can be used to detect, reduce, and prevent tip wear?

34. A Closer Look At Multi-Lane Checkweighing In Pharma 5/2/2025

    Learn how multi-lane checkweighing boosts operational efficiency, ensures accurate dosing, and simplifies changeovers, making it ideal for applications like dual-chamber sachets and nutraceutical products.

35. What Pharma And Biopharma Should Know About Container Closure Integrity 8/1/2024

    Explore high voltage leak detection, headspace analysis, and vacuum and pressure decay as applied in pharmaceutical manufacturing.

36. Experimental Design And Positive Controls For Package Integrity 4/9/2020

    Given that the experimental design has only two conditions, leaking and non-leaking, this variable is extremely important to understand. Proper use of positive controls and knowledge of how alternative approaches are applied to challenge a test method support the validity and reliability of the method.

37. Medical Device Package Inspection

    Medical device manufacturing is a labor intensive process, requiring operator involvement from manufacturing through final inspection of products. High product costs and superior quality requirements are two reasons for successful integration of airborne ultrasound seal inspection for medical device packaging. By PTI Inspection Systems

38. Headspace Oxygen Monitoring On A Pre-filled Syringe Line Filling Oxygen-Sensitive Product 12/28/2018

    This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.

39. Non-Invasive Headspace Analysis For Automated Media Fill 12/28/2018

    Explore how laser-based headspace provides an alternative approach for detecting microbial contamination in sterile products, which allows for quicker, more accurate test results.

40. Non-Destructive Options For Leak Testing Blister Packages

    Concerns about waste, human error, and cGMP compliance are leading some packaging facilities to seek alternatives to the standard blue-dye leak test for blister packaging.