Solid Dose Manufacturing Solutions

31. High Potency API Development And Manufacturing 6/18/2026

    Our HPAPI development and manufacturing spans preclinical through commercial supply across 13 global sites, with SafeBridge-certified containment and 30 years of cytotoxic compound expertise.

32. Unused 600 Liter GEA High Shear Mixer 6/4/2019

    Unused 600 liter GEA high shear mixer, model PMA 600 Advanced, 316L stainless steel product contact surfaces, 240-450 liter working capacity, 36 kw main impeller, 1-170 rpm, 11 kw chopper, 1000-3000 rpm, jacketed bowl, machine designed to 16 bar shock rating, full vacuum rated bowl, 8" side discharge with valve, integrally mounted Quadro Comil, model U20, integrally mounted blade hoist, associated control systems with Allen Bradley plc and HMI designed for class 1 div 2 area, 480 volt, with GEA temperature control unit, model PMS 600, WIP design, through the wall design mounted on base with PL600 IBC hoist with (4) approximately 750 liter IBC's, PMA 600 Advanced serial# 14369.1310, built 2015 and unused.

33. Oral Solid Dose Formulation And Lab Scale Capabilities 1/31/2024

    Natoli Scientific is dedicated to developing high-quality affordable products for your market needs.

    We provide a formulation design based on a strong scientific understanding and decoding interplay of materials and process parameters to ensure product integrity. We use traditional as well as principles of ‘Quality by Design (QbD)’ to develop robust lead prototype formulations. The early sound scientific investment in product development saves time and money during scale-up and commercial manufacturing.

34. Aseptic Pharmaceutical Isolators From Franz Ziel 9/24/2024

    Isolators with product protection as a housing for aseptic processes, e.g., filling, loading and unloading of freeze dryers.

35. Getting Solid Form Right The First Time

    We have defined work flows to assess and select solid forms in a cost and time efficient manner that meets the needs of each individual program.

36. Filling Of Powders Into Drums And Bags 8/13/2020

    Dec excels in providing comprehensive technical solutions for packing powders into bags and drums from process equipment discharge such as a dryer or a mixer, milling and dispensing to the final packing of the product.

37. Compaction Simulation / Emulation 7/30/2024

    Building on the capabilities of the NP-RD10A benchtop tablet press (discussed in our previous article on USP <1062>), our services are further enhanced by the integration of the Presster™ compaction emulator. This state-of-the-art tool is designed to replicate the compaction dynamics of production tablet presses in a laboratory setting. It allows for tangible fine-tuning of the compression cycle, providing an accurate depiction of how a tablting formulation will behave under commercial manufacturing conditions. Using the Presster, Natoli Scientific can simulate full-scale production, permitting us to forecast problems before they escalate to costly production delays. Our experts can optimize the tablet design for our clients, ensuring a smooth transition from laboratory to production while adhering to the rigorous standards set by the industry including the current USP <1062> chapter.

38. Overcoming Aseptic Manufacturing Challenges To Prevent Contamination 3/12/2022

    The pharmaceutical industry has steadily moved to increased production and handling of sterile highly potent active ingredients (HPAPIs). Dec’s containment technologies comply with pharmaceutical quality manufacturing standards and are available for aseptic operations.

39. EZ Level Feeder Table Leveling System 10/9/2025

    Stop wasting time on frustrating, trial-and-error methods to level your tablet press feeder platform. "Close enough" isn't good enough—especially when it leads to excess formulation loss or costly equipment damage. With the Natoli EZ Level™ Feeder Base Leveling System, you can achieve fast, accurate, and repeatable results—every time.

40. From Formulation To Global Supply: Mastering Oral Solid Development 4/9/2026

    A global, integrated approach to oral solid dosage development combines formulation science, advanced delivery, and scalable manufacturing to support efficient clinical progress and reliable supply.