Thermo Fisher Bioproduction Insights

  1. Understanding Viral Clearance During Anion-Exchange Chromatography 3/26/2024

    A design of experiments (DoE) study examined the anion-exchange process in general and to draw possible correlations between such properties and overall viral clearance capability.

  2. Monoclonal Antibody Aggregate Polish And Viral Clearance Using HIC 3/26/2024

    Explore highly productive POROS HIC polishing processes in both bind–elute and flowthrough modes that outcompeted legacy clinical processes designed for two highly challenging case studies (MAbs A and B).

  3. A Launchpad For Scalable Systems In AAV Gene Therapy Manufacturing 3/21/2024

    Identifying a trusted supplier that can address the myriad of challenges that accompany development for AAV-based drugs is critical to securing an asset’s ultimate commercial success.

  4. Gradient Performance Of The DynaChrom Single-Use Chromatography System 3/18/2024

    Explore a single-use chromatography system that introduces micro-efficiencies into the manufacturing workflow process, potentially leading to time and cost savings throughout the production life cycle.

  5. Viral Clearance Capability Of POROS Hydrophobic Interaction Chromatography Resins 3/11/2024

    The present study highlights the viral clearance performance of POROS HIC resins, either in FT or B/E mode, in the purification process of two monoclonal antibodies.

  6. Using Affinity Chromatography For The Purification Of Lentiviral Particles 3/11/2024

    This new affinity chromatography resin offers an efficient and scalable purification method for lentiviral particles in combination with gentle elution conditions to retain viral infectivity.

  7. Enable Custom Chromatography Solutions For Downstream Processing 3/8/2024

    This study explores the development of a POROS prototype resin, investigating ligand immobilization, optimizing coupling conditions, and evaluating bead morphology impact on resin performance.

  8. Aggregate Removal From mAbs By Hydrophobic Interaction Chromatography 3/7/2024

    Review the results of a study where Hydrophobic Interaction Chromatography (HIC) techniques were used with a resin for the removal of aggregates in the manufacturing of monoclonal antibodies.

  9. Addressing High Aggregate Challenges In Engineered mAbs 3/5/2024

    Explore a resin-based method showing promise for effectively reducing high aggregate levels in mAbs, delivering high monomer yields with low aggregate impurity levels, and enhancing mAb purification.

  10. Productivity Optimization And Process Calculations For AAV Affinity Chromatography 2/29/2024

    In this work, dynamic binding capacity (DBC) data for multiple AAV serotypes were leveraged to estimate the optimal productivity of rAAV using the AAVX resin.