Thermo Fisher Bioproduction Insights

  1. Gradient Performance Of The DynaChrom Single-Use Chromatography System 3/18/2024

    Explore a single-use chromatography system that introduces micro-efficiencies into the manufacturing workflow process, potentially leading to time and cost savings throughout the production life cycle.

  2. Viral Clearance Capability Of POROS Hydrophobic Interaction Chromatography Resins 3/11/2024

    The present study highlights the viral clearance performance of POROS HIC resins, either in FT or B/E mode, in the purification process of two monoclonal antibodies.

  3. Using Affinity Chromatography For The Purification Of Lentiviral Particles 3/11/2024

    This new affinity chromatography resin offers an efficient and scalable purification method for lentiviral particles in combination with gentle elution conditions to retain viral infectivity.

  4. Enable Custom Chromatography Solutions For Downstream Processing 3/8/2024

    This study explores the development of a POROS prototype resin, investigating ligand immobilization, optimizing coupling conditions, and evaluating bead morphology impact on resin performance.

  5. Aggregate Removal From mAbs By Hydrophobic Interaction Chromatography 3/7/2024

    Review the results of a study where Hydrophobic Interaction Chromatography (HIC) techniques were used with a resin for the removal of aggregates in the manufacturing of monoclonal antibodies.

  6. Addressing High Aggregate Challenges In Engineered mAbs 3/5/2024

    Explore a resin-based method showing promise for effectively reducing high aggregate levels in mAbs, delivering high monomer yields with low aggregate impurity levels, and enhancing mAb purification.

  7. Productivity Optimization And Process Calculations For AAV Affinity Chromatography 2/29/2024

    In this work, dynamic binding capacity (DBC) data for multiple AAV serotypes were leveraged to estimate the optimal productivity of rAAV using the AAVX resin.

  8. POROS Benzyl Ultra Viral Clearance And Impurity Removal For A Novel Antibody Format 2/26/2024

    A firm that develops innovative ADCs for cancer treatments, has been exploring the effectiveness of POROS™ Benzyl Ultra, a hydrophobic interaction chromatography resin, in reducing HMW species.

  9. Uninterrupted Supply To Meet Demand 1/23/2024

    Explore a solution for biopharmaceutical companies concerned about the risks an increase in campaign volume can pose to their production timeline.

  10. Reducing Lead Time, Delivering >99.5% OTIF 1/23/2024

    Explore the stocking solution offered to a mid-sized CDMO in need of a high volume of safety stock inventory to support their customer portfolio growth.