FEATURED ARTICLES

WHITE PAPERS & CASE STUDIES

  • Agglomerate-Free Dispersion For Hand Sanitizers

    Obtaining an agglomerate-free dispersion is essential to ensure a clear, bright gel after neutralization but low density powders such as Carbopol can be difficult to incorporate into liquids with a conventional agitator. The high shear mixing of a Silverson mixer ensures rapid incorporation and dispersion of powders to form an agglomerate-free solution, with minimized aeration.

  • Line Of Sight - Enabling Lyophilization Scale-Up From Formulation To Full Commercial Production

    Line of Sight suite of freeze-drying equipment with scalable lyophilization technologies and process analytical technology (PAT) tools have been developed to provide the tools for a more successful scale-up of a lyophilization process from formulation through to full commercial production. This ensures superior product quality and uniformity and creates a data rich environment across all sizes of freeze-drying systems.

  • Enabling Lyophilization Scale-Up From Formulation To Full Commercial Production

    Biologic drugs have shown great promise in curing many life changing diseases, even some that were once thought incurable. However, due to the sensitive nature of  biological material it requires specialized development and manufacturing processes. Stabilization by lyophilization is attractive to retain the product’s biological activity, structural integrity and homogenous quality, all of which are crucial to the success of the product. This white paper describes the challenges associated with lyophilization of biologic drug products.

PRODUCTS & SERVICES

The patented loading system for freeze dryers ensures maximum process safety, while saving a considerable amount of space. Thanks to its new front pusher design, the system loads vials into the freeze dryer using the linear pushing and pulling motion of a transfer arm. Unlike other systems, the innovative transfer bar is not moved by a hydraulic push rod, but by a mechanical servo drive.

Pharmatec Process Systems for Biopharmaceutical Production are designed for the production of liquid medicines. Production of pharmaceutical liquids is carried out in temperature-controlled stainless steel tanks with stirring units under addition of chemicals with or without nutrient solutions. All valid pharmaceutical (e. g. USP, EP) and technical rules and standards (e. g. DIN, ASME, GMP and FDA / ISPE Guidelines) are followed and applied.

Roller compaction is a proven process providing a method of granulation for materials that are known to be sensitive to heat and/or moisture.