Technical Considerations For Developing Oral Solids (Part 2)
What technical considerations should be at the forefront for your oral solids project? This two-part series features four oral solids experts from Pfizer CentreOne’s global network and partner organizations discussing the technical considerations to be aware of. In the second installment of the series, our experts consider the effects of equipment design and different tablet strategies.
WHITE PAPERS & CASE STUDIES
Pediatric Dosage Form Considerations For Highly Potent Compounds
The development of pediatric medicine poses numerous challenges to pharmaceutical formulators, particularly products intended for infants and very young children. This white paper describes special considerations for selecting appropriate pediatric dosage forms and the benefits of choosing mini-tablets (e.g., orodispensible) for pediatric formulation, particularly for highly potent compounds.
Extrusion- Spheronization, Engineered For Today’s Controlled Release Forms
Synchronizing and controlling API delivery, extrusion-spheronization offers pharmaceutical companies a robust technique to manufacture today’s most complex therapeutics. With the right capabilities, this well-understood process stands ready to help lead the development and manufacturing of both today’s and tomorrow’s complex OSD therapeutics.
Identifying Abrasive Wear Risks In Tableting Tooling For Nutraceutical Products
Tablet presses are used to manufacture a variety of products, such as pharmaceuticals, nutraceuticals, veterinarian products, confectionary, and industrial tablets. Each industry faces unique challenges due to the properties inherent to any particular formulation. A variety of steel types/coatings, tool design modifications/options, and tablet design recommendations can work together to increase tool life and improve tablet quality.
Overcoming Encapsulation Issues Caused By Sticky Formulations
This guide provides a best-practices approach to troubleshooting capsule-filling problems when handling a sticky product formulation.
Considerations When Cleaning Your Tablet Presses & Tablet Tooling
Implementing a cleaning procedure is essential to maintaining your tablet tooling and presses. Dirty tools cause tableting and product quality-related problems, such as sticking & picking. Keeping tools clean also decreases premature tool, turret and cam wear, and reduces the risk of product cross-contamination. While most cleaning methods can achieve similar results, utilizing an automated cleaning system, such as an ultrasonic wash with rinse and dryer, can ensure tooling is properly cleaned and dried consistently with limited handling and potential for damage. A warm air-drying process is ideal for preventing moisture and corrosion by pushing warm air through areas, such as key slots, punch cups, and die bores, that may not be dried properly with a traditional towel or cloth.
In-Situ, Non-Destructive Surface Area Measurement For The Optimal Application Of Lyophilization
A key focus of this paper is the relevant measurement of surface area, with experimental data demonstrating the performance and value of novel instrumentation for in-situ characterization.