Ensuring The Efficacy Of Probiotic Products
There is growing interest among consumers in verifying that the dietary supplements they take are safe and efficacious. The concern over whether consumers are getting the product as it is described on the label is rooted in one vital and transformative fact: probiotics are living organisms that are highly sensitive to humidity and oxygen. In the absence of proper handling and packaging, the efficacy of probiotic products can be compromised at any point of the packaging, storage and transportation process, inversely impacting shelf life and product viability and efficacy for the consumer.
WHITE PAPERS & CASE STUDIES
Identifying Abrasive Wear Risks In Tableting Tooling For Nutraceutical Products
Tablet presses are used to manufacture a variety of products, such as pharmaceuticals, nutraceuticals, veterinarian products, confectionary, and industrial tablets. Each industry faces unique challenges due to the properties inherent to any particular formulation. A variety of steel types/coatings, tool design modifications/options, and tablet design recommendations can work together to increase tool life and improve tablet quality.
Overcoming Encapsulation Issues Caused By Sticky Formulations
This guide provides a best-practices approach to troubleshooting capsule-filling problems when handling a sticky product formulation.
Considerations When Cleaning Your Tablet Presses & Tablet Tooling
Implementing a cleaning procedure is essential to maintaining your tablet tooling and presses. Dirty tools cause tableting and product quality-related problems, such as sticking & picking. Keeping tools clean also decreases premature tool, turret and cam wear, and reduces the risk of product cross-contamination. While most cleaning methods can achieve similar results, utilizing an automated cleaning system, such as an ultrasonic wash with rinse and dryer, can ensure tooling is properly cleaned and dried consistently with limited handling and potential for damage. A warm air-drying process is ideal for preventing moisture and corrosion by pushing warm air through areas, such as key slots, punch cups, and die bores, that may not be dried properly with a traditional towel or cloth.
In-Situ, Non-Destructive Surface Area Measurement For The Optimal Application Of Lyophilization
A key focus of this paper is the relevant measurement of surface area, with experimental data demonstrating the performance and value of novel instrumentation for in-situ characterization.
Preventing Sticking And Picking Through Tablet Design
Sticking or picking issues are often not detected. Prevent unanticipated problems during scale-up and full-scale production by considering tablet compression issues before tablet designs are finalized.
Breaking The Misconceptions Of Maximum Compression Force
With proper formulation development and tablet design the tablet press operator should be able to manufacture quality tablets without exceeding the tooling’s maximum compression force rating.