FEATURED ARTICLES

• Why Spray Drying Is Gaining Attention

  Facing patent cliffs, pharma companies can leverage spray drying to reformulate complex biologics, enabling non-invasive delivery, boosting patient convenience, and securing new patents.

• De-Risking Production Of Complex Oral Solid Dosages: Considerations & Key Capabilities
• The Future Of Continuous Is Integrated Manufacturing: The 4 Misconceptions About A Lean Process
• Optimising Solubility: Selecting The Right Technology For Early Drug Development
• How Generic Pharma Manufacturers Can Rebuild Margins Inside The Four Walls

WHITE PAPERS & CASE STUDIES

• Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling

  Learn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.

• Compaction Simulation For Tablet Technology Transfer And Scale-Up

  Compaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.

• Predicting Softgel Stability And Shelf Life Using Accelerated Modeling

  Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.

• Predicting Drug-Loading Limits In Tablet Formulations

  Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.

• Modeling Polymer Interactions To Improve Amorphous Solid Dispersion Stability

  Molecular dynamics modeling revealed how hydrogen bonding between PVP and Eudragit drives stable amorphous solid dispersion formation, cutting formulation screening time significantly.

• Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies

  In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.