How conducting studies on a formulation during R&D and scale-up can help identify and solve potential powder flow issues before moving into commercial production.
Mixer testing simulation trials are needed to confirm the suitability of a specific mixing strategy. This white paper explores five ways to increase energy efficiency in new and existing mixing processes.
Natoli Engineering Company recently completed a successful Factory Acceptance Test (FAT) with a top-tier cosmetics company.
When scaling a new drug formulation from the development side of R&D into manufacturing, there is often a reality check with respect to process scale- up and performance of the formulation at production levels. By Chuck Kettler, Director, Natoli Scientific of Natoli Engineering Company, Inc.
Almac has developed a flexible pediatric dosage form consisting of minitablets filled into stickpacks using a robust manufacturing and filling process suitable for routine commercial manufacture.
Providing support in all aspects of the tablet compression process should be expected from your tooling and tablet press partner.
Clinical studies on solid dose products may require a placebo. The placebo, in the case of a tablet, should possess the same shape and color compared to the active product.
Natoli Engineering is quickly becoming the leader in R&D tablet presses with this next-generation rotary tablet press. Designed to help solve formulation and scale-up challenges, the NP-RD30 rotary R&D tablet press replicates the design and functionality of a production press. The turret velocity of the NP-RD30 can reach that of production presses, meaning dwell time can be more accurately established during research and development.
Natoli Quick-Release Tablet Tooling allows researchers to test different dwell times during the tablet R&D process without the expense of buying several different sets of tools or the time needed to change complete sets of tooling or turret speed.
Coperion K-Tron provides a variety of control options to meet a client's process needs. From standard equipment controls to interface options for both the pneumatic conveying systems as well as feeder controls, Coperion K-Tron is dedicated to ensure the client's specific process control requirements are met.
With over 100 years of experience in feeding technology, Coperion K-Tron development and engineering teams are experts at creating smart feeding solutions.
Coperion K-Tron's machine controllers and operator interfaces deliver full functional flexibility and the connectivity you need. Coperion K-Tron’s SmartConnex control environment provides comprehensive control capability with maximum flexibility and connectivity for systems up to 24 weigh belt feeders, loss-in-weight feeders, volumetric feeders, batchers, flow meters, Bulk Solids Pump (BSP) feeders or PID controlled devices as well as pneumatic refill systems.
Coperion K-Tron’s liquid loss-in-weight feeders provide accurate continuous volumetric or gravimetric flow control of liquids. The highly accurate gravimetric units combine the pump and tank with a suspension scale or platform scale; the feed pump for metering the material is located outside the scale area.
When handling powder and pellets, a plant constructor can only design a reliably functioning and economical bulk material handing system with in-depth knowledge and comprehensive understanding of the complex behavior of bulk materials.
Coperion Strand Pelletizers are ideal for the manufacturing of pharmaceutical drug products.
