Package integrity is defined as a package’s ability to prevent product loss, maintain product sterility, and in some cases, prevent oxygen ingress or maintain sub-atmosphere headspace pressures.
This guide explains the concept of metal detector sensitivity, key factors that impact it, and why a small difference in spherical sensitivity performance can mean a big difference in contaminants detected.
This white paper provides an explanation of the differences between validation, verification and routine performance monitoring as well as an overview of recommended test methods for different types of metal detection systems.
Rapid water vapor determination with an optical method could replace the slow destructive traditional methods for the moisture analysis of freeze-dried product. A description of industry applications of headspace moisture analysis including freeze drying cycle optimization, lyo chamber moisture distribution mapping, and 100% moisture inspection of commercial freeze-dried product.
A vaccine-focused biotechnology company approached LIGHTHOUSE to help investigate a phenomenon observed in liquid vaccine product stored at -80°C. During QC testing, a number of vials were found to have an overpressure. This phenomenon represented a serious safety risk and LIGHTHOUSE was asked to support an investigation to identify the root cause.
Laser-based headspace provides yet another alternative approach for detecting microbial contamination in sterile pharmaceutical product allows for quicker, more sensitive, accurate, and reproducible test results when compared with conventional, growth-based methods.
This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.
Ideal medical devices and medical packaging leak testing. Unlike pressure decay, we offer a faster and higher sensitivity test as well as direct measurements that are not volume sensitive, allowing for less set up, no frequent calibration required, less qualification, and therefore, a more robust operation.
The SC-E model is the perfect entry to the world of ultra-modern X-ray inspection systems and the associated high quality product line of WIPOTEC-OCS.
Top-down X-ray scanners inspect the product from above and for this the camera taking the image is located underneath the conveyor belt. This construction is always chosen when the height of the products is low compared to their surface area.
WIPOTEC-OCS provides a reliable and robust combination of checkweigher and metal detection in an innovative, hygienic Wash Down design. This model meets all statutory provisions for the food processing industry like IFS-compliant product control, and HACCP or LMHV/FDA (Food Hygiene Regulations).
This machine is for heavy load and a high-tech combination scale and metal detector, together in one compact unit that sets the quality standard in terms of product safety.
The HC-A-MDi checkweigher / metal detector model is synonymous with high precision weighing in combination with extremely sensitive metal detection for optimal performance. It is a practical combination of inspection technologies in the interests of increased consumer safety and provides scales and metal detector in one space-saving unit, which can be operated from one HMI and easily integrated as part of any line.
If high-precision weighing of products is not enough and it requires an additional reliable inspection for metallic impurities, there is the HC-M-MDi checkweigher / metal detector system.
Aseptic sampling devices are a critical component in an effective microbial control program. Samples collected with TAKEONE® are used to measure critical purity attributes such as bioburden, sterility and endotoxin levels and important process parameters like metabolites, nutrients, osmolality, pH and more. The TAKEONE® aseptic sampling device is a pre-assembled and single-use sampling solution. The 1,5" or 2" device has 5 or 9 fully-closed and independent sampling lines. TAKEONE® collects perfectly representative samples giving exact results with no risk of false positives.
