Package integrity is defined as a package’s ability to prevent product loss, maintain product sterility, and in some cases, prevent oxygen ingress or maintain sub-atmosphere headspace pressures.
This guide explains the concept of metal detector sensitivity, key factors that impact it, and why a small difference in spherical sensitivity performance can mean a big difference in contaminants detected.
This white paper provides an explanation of the differences between validation, verification and routine performance monitoring as well as an overview of recommended test methods for different types of metal detection systems.
Rapid water vapor determination with an optical method could replace the slow destructive traditional methods for the moisture analysis of freeze-dried product. A description of industry applications of headspace moisture analysis including freeze drying cycle optimization, lyo chamber moisture distribution mapping, and 100% moisture inspection of commercial freeze-dried product.
A vaccine-focused biotechnology company approached LIGHTHOUSE to help investigate a phenomenon observed in liquid vaccine product stored at -80°C. During QC testing, a number of vials were found to have an overpressure. This phenomenon represented a serious safety risk and LIGHTHOUSE was asked to support an investigation to identify the root cause.
Laser-based headspace provides yet another alternative approach for detecting microbial contamination in sterile pharmaceutical product allows for quicker, more sensitive, accurate, and reproducible test results when compared with conventional, growth-based methods.
This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.
ATC's Mass Extraction Technology takes advantage of the Micro-Flow phenomena and gas expansion, which occurs while the test is conducted in a vacuum.
The Thermo Scientific Versa Rx checkweigher provides superior quality to meet the most demanding performance standards.
Achieve cost-effective, industry-leading sensitivity in the most demanding pharmaceutical applications. The Thermo Scientific APEX 500 Rx Metal Detector offers the highest level of brand protection in the most demanding pharmaceutical environments.
Find metallic and non-metallic foreign objects using our entry-level X-ray inspection system
A general-purpose precision checkweigher with a cantilever design that scans at line speeds up to 350 packages per minute.
The quality, safety and effectiveness of drugs significantly depends on their proper packaging.
A versatile, scalable, fixed-height checkweigher ideal for products up to 10kg (22 pounds).
Our Medical Device Leak And Flow Testing capabilities surpass other existing methods. We offer nondestructive (NDT) leak testing instruments for your flexible and rigid products.
