Package integrity is defined as a package’s ability to prevent product loss, maintain product sterility, and in some cases, prevent oxygen ingress or maintain sub-atmosphere headspace pressures.
Rapid water vapor determination with an optical method could replace the slow destructive traditional methods for the moisture analysis of freeze-dried product. A description of industry applications of headspace moisture analysis including freeze drying cycle optimization, lyo chamber moisture distribution mapping, and 100% moisture inspection of commercial freeze-dried product.
A vaccine-focused biotechnology company approached LIGHTHOUSE to help investigate a phenomenon observed in liquid vaccine product stored at -80°C. During QC testing, a number of vials were found to have an overpressure. This phenomenon represented a serious safety risk and LIGHTHOUSE was asked to support an investigation to identify the root cause.
Laser-based headspace provides yet another alternative approach for detecting microbial contamination in sterile pharmaceutical product allows for quicker, more sensitive, accurate, and reproducible test results when compared with conventional, growth-based methods.
This application note describes how laser-based headspace analysis is used for the rapid non-destructive determination of headspace oxygen levels in pre-filled syringes. Data is presented demonstrating two major applications of this technique: 1) headspace oxygen monitoring on a pre-filled syringe line filling oxygen-sensitive product, and 2) container closure testing of pre-filled syringes.
How non-destructive headspace analysis information can be critical for QC groups performing stability studies, or for packaging development groups responsible for choosing the optimal primary packaging configuration.
Rapid non-destructive headspace moisture analysis from LIGHTHOUSE enables fast moisture determination of statistical numbers of lyo samples.
The SC-E model is the perfect entry to the world of ultra-modern X-ray inspection systems and the associated high quality product line of WIPOTEC-OCS.
Top-down X-ray scanners inspect the product from above and for this the camera taking the image is located underneath the conveyor belt. This construction is always chosen when the height of the products is low compared to their surface area.
WIPOTEC-OCS provides a reliable and robust combination of checkweigher and metal detection in an innovative, hygienic Wash Down design. This model meets all statutory provisions for the food processing industry like IFS-compliant product control, and HACCP or LMHV/FDA (Food Hygiene Regulations).
This machine is for heavy load and a high-tech combination scale and metal detector, together in one compact unit that sets the quality standard in terms of product safety.
The HC-A-MDi checkweigher / metal detector model is synonymous with high precision weighing in combination with extremely sensitive metal detection for optimal performance. It is a practical combination of inspection technologies in the interests of increased consumer safety and provides scales and metal detector in one space-saving unit, which can be operated from one HMI and easily integrated as part of any line.
If high precision weighing of your products is not enough and you require an additional reliable inspection for metallic impurities, you need the HC-M-MDi checkweigher / metal detector system.
Aseptic sampling devices are a critical component in an effective microbial control program. Samples collected with TAKEONE® are used to measure critical purity attributes such as bioburden, sterility and endotoxin levels and important process parameters like metabolites, nutrients, osmolality, pH and more. The TAKEONE® aseptic sampling device is a pre-assembled and single-use sampling solution. The 1,5" or 2" device has 5 or 9 fully-closed and independent sampling lines. TAKEONE® collects perfectly representative samples giving exact results with no risk of false positives.
GlobalVision Color Inspection is the first digital inspection solution for color management for PDFs and printed components. The tool inspects colors and reports any differences outside a defined color threshold. Instead of manually checking colors by eye, users can detect and communicate color differences with color reports alongside their proofs for approval.
